Infliximab and Methotrexate Interaction
Drug interaction information between Infliximab and Methotrexate.
Infliximab and Methotrexate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Infliximab and Methotrexate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There is no specific information available on how these two drugs interact because clinical studies have not been performed.
FDA Label Information
7.2 Methotrexate and Other Concomitant Medications Specific drug interaction studies, including interactions with methotrexate (MTX), have not been conducted.
Infliximab Also Interacts With
- Abatacept moderate
- Folic Acid minor
- Warfarin minor
- Ciprofloxacin minor
- Cyclosporine minor
Methotrexate Also Interacts With
- Celecoxib moderate
- Diflunisal moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
Frequently Asked Questions
What SPL severity band is on file for Infliximab + Methotrexate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methotrexate has 38 labeled pairs on file vs Infliximab's 8. In the minor band specifically: Infliximab has 7 (also Folic Acid, Warfarin, Ciprofloxacin, Cyclosporine); Methotrexate has 26 (also Aspirin, Folic Acid, Probenecid, Phenytoin).
What mechanism field is on file for Infliximab and Methotrexate?
There is no specific information available on how these two drugs interact because clinical studies have not been performed.
Methotrexate's labeled portfolio outnumbers Infliximab
SPL source-record counts only. This page's band is minor · classes on file: Infliximab (TNF-Alpha Inhibitor (Biologic)); Methotrexate (Disease-Modifying Antirheumatic Drug (DMARD)).
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Infliximab
- Folic Acid
- Warfarin
- Ciprofloxacin
- Cyclosporine
0 major · 12 moderate · 26 minor · 38 total
- Other minor peers for Methotrexate
- Aspirin
- Folic Acid
- Probenecid
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.