Folic Acid and Prenatal Multivitamin Interaction
Drug interaction information between Folic Acid and Prenatal Multivitamin.
Folic Acid and Prenatal Multivitamin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Folic Acid and Prenatal Multivitamin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking a folic acid supplement along with a multivitamin that already contains it increases the total amount of this vitamin in your body.
FDA Label Information
• Additionally, concurrent use of folic acid has been associated with enhanced phenytoin metabolism, lowering the level of the AED in the blood and allowing breakthrough seizures to occur. • Cholestyramine: Reduces folic acid absorption and reduces serum folate levels. • Colestipol: Reduces folic acid absorption and reduces serum folate levels.
Folic Acid Also Interacts With
- Dapsone Topical minor
- Infliximab minor
- Methotrexate minor
- Phenytoin minor
Prenatal Multivitamin Also Interacts With
- Trimethoprim moderate
- Phenytoin moderate
- Metformin minor
- Fluoxetine minor
- Ibuprofen minor
Frequently Asked Questions
What SPL severity band is on file for Folic Acid + Prenatal Multivitamin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Prenatal Multivitamin has 23 labeled pairs on file vs Folic Acid's 5. In the minor band specifically: Folic Acid has 5 (also Dapsone Topical, Infliximab, Methotrexate, Phenytoin); Prenatal Multivitamin has 21 (also Metformin, Fluoxetine, Ibuprofen, Potassium Chloride).
What mechanism field is on file for Folic Acid and Prenatal Multivitamin?
Taking a folic acid supplement along with a multivitamin that already contains it increases the total amount of this vitamin in your body.
Prenatal Multivitamin's labeled portfolio outnumbers Folic Acid
SPL source-record counts only. This page's band is minor · classes on file: Folic Acid (B Vitamin (Folate) Supplement); Prenatal Multivitamin (Prenatal Vitamin).
0 major · 0 moderate · 5 minor · 5 total
- Other minor peers for Folic Acid
- Dapsone Topical
- Infliximab
- Methotrexate
- Phenytoin
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Prenatal Multivitamin
- Metformin
- Fluoxetine
- Ibuprofen
- Potassium Chloride
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.