Folic Acid and Dapsone Topical Interaction
Drug interaction information between Folic Acid and Dapsone Topical.
Folic Acid and Dapsone Topical have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Folic Acid and Dapsone Topical. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these drugs together can increase the chance of having blood problems because they both affect how your body handles folic acid.
FDA Label Information
With oral dapsone treatment, folic acid antagonists such as pyrimethamine have been noted to possibly increase the likelihood of hematologic reactions.
Folic Acid Also Interacts With
- Infliximab minor
- Methotrexate minor
- Phenytoin minor
- Prenatal Multivitamin minor
Dapsone Topical Also Interacts With
- Acetaminophen moderate
- Nitrofurantoin moderate
- Chloroquine moderate
- Nitroglycerin moderate
- Phenytoin moderate
Frequently Asked Questions
What SPL severity band is on file for Folic Acid + Dapsone Topical?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dapsone Topical has 10 labeled pairs on file vs Folic Acid's 5. In the minor band specifically: Folic Acid has 5 (also Infliximab, Methotrexate, Phenytoin, Prenatal Multivitamin); Dapsone Topical has 4 (also Trimethoprim, Rifampin, Benzoyl Peroxide).
What mechanism field is on file for Folic Acid and Dapsone Topical?
Using these drugs together can increase the chance of having blood problems because they both affect how your body handles folic acid.
Dapsone Topical's labeled portfolio outnumbers Folic Acid
SPL source-record counts only. This page's band is minor · classes on file: Folic Acid (B Vitamin (Folate) Supplement); Dapsone Topical (Topical Anti-Inflammatory).
0 major · 0 moderate · 5 minor · 5 total
- Other minor peers for Folic Acid
- Infliximab
- Methotrexate
- Phenytoin
- Prenatal Multivitamin
0 major · 6 moderate · 4 minor · 10 total
- Other minor peers for Dapsone Topical
- Trimethoprim
- Rifampin
- Benzoyl Peroxide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.