Infliximab and Warfarin Interaction
Drug interaction information between Infliximab and Warfarin.
Infliximab and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Infliximab and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Infliximab can change how the liver breaks down other drugs like warfarin. This can cause the amount of warfarin in your body to change when you start or stop treatment.
FDA Label Information
Upon initiation or discontinuation of INFLECTRA in patients being treated with CYP450 substrates with a narrow therapeutic index, monitoring of the effect (e.g., warfarin) or drug concentration (e.g., cyclosporine or theophylline) is recommended and the individual dose of the drug product may be adjusted as needed.
Infliximab Also Interacts With
- Abatacept moderate
- Folic Acid minor
- Methotrexate minor
- Ciprofloxacin minor
- Cyclosporine minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Infliximab + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Infliximab's 8. In the minor band specifically: Infliximab has 7 (also Folic Acid, Methotrexate, Ciprofloxacin, Cyclosporine); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Infliximab and Warfarin?
Infliximab can change how the liver breaks down other drugs like warfarin. This can cause the amount of warfarin in your body to change when you start or stop treatment.
Warfarin carries more major-labeled pairs than Infliximab
SPL source-record counts only. This page's band is minor · classes on file: Infliximab (TNF-Alpha Inhibitor (Biologic)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Infliximab's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Infliximab
- Folic Acid
- Methotrexate
- Ciprofloxacin
- Cyclosporine
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.