hydrochlorothiazide/losartan vs lithium
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Side-by-side comparison of hydrochlorothiazide/losartan and lithium. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
( 7.1 ) Lithium: Risk of lithium toxicity. 7.2 Lithium Increases in serum lithium concentrations and lithium toxicity have been reported with concomitant use of angiotensin II receptor antagonists or thiazide diuretics. Monitor lithium levels in patients receiving HYZAAR and lithium.
Hyzaar
Lithobid, Eskalith
Hyzaar is a combination medicine that contains losartan and hydrochlorothiazide. It is used to lower high blood pressure.
Lithium is a mood stabilizer medicine. It helps to balance mood swings.
Hyzaar is used to treat high blood pressure. Lowering blood pressure reduces your risk of strokes and heart attacks. It is also used to lower the risk of stroke in patients with high blood pressure and an enlarged left ventricle of the heart.
Lithium is used to treat bipolar disorder. Bipolar disorder causes unusual shifts in mood, energy, activity levels, and concentration. Lithium helps to control the extreme highs (mania) and lows (depression) of this condition.
Losartan blocks a substance in your body that tightens blood vessels. This helps blood vessels relax, which lowers blood pressure. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water, which also lowers blood pressure.
Lithium affects the flow of sodium in nerve and muscle cells in the body. This helps to stabilize your mood. It may also affect other chemical messenger systems in the brain.
- • Dizziness
- • Upper respiratory infection
- • Cough
- • Back pain
- • Tremor (shaking)
- • Nausea
- • Increased weight
- • Fatigue (feeling tired)
- • Vomiting
- Tiredness 10,013
- Feeling sick to your stomach 9,706
- Loose stools 8,311
- Discomfort 7,665
- Difficulty breathing 7,584
- Toxicity To Various Agents 2,179
- Drug Interaction 1,526
- Tremor 1,462
- Nausea 1,344
- Weight Increased 1,153
If you are pregnant or plan to become pregnant, stop taking Hyzaar and tell your doctor right away. This medicine can harm or kill your unborn baby.
Lithium levels in your blood need to be monitored closely by your doctor. Too much lithium can be toxic and cause serious side effects. Make sure to attend all scheduled blood tests.
Do not take Hyzaar if you are pregnant. It can cause serious harm to your unborn baby, including kidney problems, lung problems, skeletal problems and even death. If you are breastfeeding, talk to your doctor about whether Hyzaar is right for you.
Lithium can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Lithium can pass into breast milk and may harm a nursing infant. Talk to your doctor about the best way to feed your baby if you are taking lithium.
How to Read This hydrochlorothiazide/losartan vs lithium Comparison
hydrochlorothiazide/losartan is classified in the Thiazide Diuretic / ARB Combination drug class, while lithium sits within the Mood Stabilizer class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, hydrochlorothiazide/losartan has 43,279 submissions while lithium has 7,664. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to these blood pressure medications can cause the amount of lithium in your body to rise to dangerous levels. this happens because the drugs change how your kidneys get rid of lithium.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for hydrochlorothiazide/losartan or lithium.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.