What the FDA labels say about taking them together
Fluvastatin and niacin
Fluvastatin's FDA label of April 21, 2025 names niacin in its drug interactions section; niacin's label does not name fluvastatin itself but warns about its class (Statins). The fluvastatin label: “The risk of myopathy and/or rhabdomyolysis with statins is increased with concurrent therapy with cyclosporine, erythromycin, fibrates or niacin.”
Check it at the source: the fluvastatin FDA label on DailyMed (effective April 21, 2025, Teva Pharmaceuticals USA, Inc.); the niacin FDA label on DailyMed (effective February 14, 2023, Aurobindo Pharma Limited).
What does the fluvastatin label say about niacin?
Fluvastatin label, drug interactionsLimit fluvastatin dose to 20 mg ( 2.5 , 7.2 ) Concomitant lipid-lowering therapies: Use with fibrates or lipid-modifying doses (≥ 1 g/day) of niacin increases the risk of adverse skeletal muscle effects.
Fluvastatin label, warnings and precautionsThe risk of myopathy and/or rhabdomyolysis with statins is increased with concurrent therapy with cyclosporine, erythromycin, fibrates or niacin.
Fluvastatin Sodium Er label (Sandoz Inc, January 31, 2024), drug interactionsClinical impact; Risk of myopathy and rhabdomyolysis may be enhanced with concomitant use with lipid-modifying doses (≥ 1 g/day) of niacin with fluvastatin sodium extended-release tablets.
Fluvastatin Sodium Er label (Sandoz Inc, January 31, 2024), warnings and precautionsWhen used concomitantly with fluvastatin sodium extended-release tablets, lipid modifying doses (≥ 1 g/day) of niacin, fibrates, and colchicine may also increase the risk of myopathy and rhabdomyolysis [see Drug Interactions ( 7.1 )].
Source: FDA drug label (Fluvastatin Sodium Er, NDA021192), Sandoz Inc, effective January 31, 2024 (SPL set 5ab4296c-87c2-4c64-b218-d620eef51310), via openFDA
Source: FDA drug label (Fluvastatin), Teva Pharmaceuticals USA, Inc., effective April 21, 2025 (SPL set aad8b373-0aec-4efb-8e61-3d8114b31127), via openFDA; the full label on DailyMed
What does the niacin label say about fluvastatin?
Niacin's label does not name fluvastatin itself; it warns about its class (Statins):
Niacin label, drug interactionsCaution should be used when prescribing niacin with statins as these agents can increase risk of myopathy/rhabdomyolysis.
Niacin label, drug interactionsCaution should be used when prescribing niacin (≥1 gm/day) with statins as these drugs can increase risk of myopathy/rhabdomyolysis [see Warnings and Precautions (5) and Clinical Pharmacology (12.3) ].
Source: FDA drug label (Niacin), Aurobindo Pharma Limited, effective February 14, 2023 (SPL set 43233a21-3f90-4c69-bbeb-f50d5f2d35ae), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluvastatin | Niacin | |
|---|---|---|
| Labeled for | High cholesterol | High cholesterol, Heart attack and coronary artery disease, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.88 per tablet 80 mg tablet | $0.193 per tablet 500 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once