Fluvastatin and Niacin Interaction
Drug interaction information between Fluvastatin and Niacin.
Fluvastatin and Niacin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fluvastatin and Niacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs increases the chance of experiencing muscle pain or damage.
FDA Label Information
Limit fluvastatin dose to 20 mg ( 2.5 , 7.2 ) Concomitant lipid-lowering therapies: Use with fibrates or lipid-modifying doses (≥ 1 g/day) of niacin increases the risk of adverse skeletal muscle effects. 7.5 Niacin The risk of skeletal muscle effects may be enhanced when fluvastatin sodium is used in combination with lipid-modifying doses (≥ 1 g/day) of niacin; a reduction in fluvastatin sodium dosage should be considered in this setting [see Warnings and Precautions ( 5.1 )].
Fluvastatin Also Interacts With
- Clarithromycin major
- Cyclosporine moderate
- Glyburide moderate
- Gemfibrozil moderate
- Phenytoin moderate
Niacin Also Interacts With
- Atorvastatin moderate
- Ezetimibe moderate
- Ezetimibe/Simvastatin moderate
- Lovastatin moderate
- Pitavastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Fluvastatin + Niacin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Niacin has 21 labeled pairs on file vs Fluvastatin's 12. In the moderate band specifically: Fluvastatin has 6 (also Cyclosporine, Glyburide, Gemfibrozil, Phenytoin); Niacin has 10 (also Atorvastatin, Ezetimibe, Ezetimibe/Simvastatin, Lovastatin).
What mechanism field is on file for Fluvastatin and Niacin?
Combining these drugs increases the chance of experiencing muscle pain or damage.
Fluvastatin carries more major-labeled pairs than Niacin
SPL source-record counts only. This page's band is moderate · classes on file: Fluvastatin (HMG-CoA Reductase Inhibitor (Statin)); Niacin (Vitamin B3 (Lipid-Modifying)).
Fluvastatin has 1 major-labeled pair vs Niacin's 0. This page itself is in the moderate band, not the major band.
1 major · 6 moderate · 5 minor · 12 total
- Other moderate peers for Fluvastatin
- Cyclosporine
- Glyburide
- Gemfibrozil
- Phenytoin
0 major · 10 moderate · 11 minor · 21 total
- Other moderate peers for Niacin
- Atorvastatin
- Ezetimibe
- Ezetimibe/Simvastatin
- Lovastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.