fluconazole vs glyburide
Side-by-side comparison of fluconazole and glyburide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
(See CONTRAINDICATIONS and PRECAUTIONS .) Oral hypoglycemics: The effects of fluconazole on the pharmacokinetics of the sulfonylurea oral hypoglycemic agents tolbutamide, glipizide, and glyburide were evaluated in three placebo-controlled studies in normal volunteers. (See PRECAUTIONS .) Glyburide: The AUC and C max of glyburide (5 mg single dose) were significantly increased following the administration of fluconazole in 20 normal male volunteers. Five subjects required oral glucose following the ingestion of glyburide after 7 days of fluconazole administration.
Recommendation: Monitor your blood sugar levels very closely for signs of hypoglycemia. Your doctor may need to adjust your glyburide dose while you are taking fluconazole.
Diflucan
DiaBeta, Glynase
Fluconazole is an antifungal medicine. It is used to treat infections caused by fungus.
Glyburide is a medicine that helps lower blood sugar in adults with type 2 diabetes. It works along with diet and exercise.
Fluconazole treats vaginal yeast infections. It also treats yeast infections in the mouth and esophagus. Fluconazole can also treat urinary tract infections, peritonitis, systemic Candida infections, and pneumonia. It can also treat cryptococcal meningitis. Fluconazole can also prevent candidiasis in patients undergoing bone marrow transplantation.
Glyburide is used to help control blood sugar levels in adults who have type 2 diabetes. It is prescribed in addition to diet and exercise. This medicine helps your body use insulin better, which lowers your blood sugar.
Fluconazole works by stopping the growth of fungi. It blocks the fungus from producing a substance it needs to grow. This helps to clear up the infection.
Glyburide belongs to a class of drugs called sulfonylureas. It works by helping your pancreas release more insulin. Insulin then helps move sugar from your blood into your cells for energy.
- • Headache
- • Nausea
- • Abdominal pain
- • Nausea
- • Heartburn
- • Fullness in your upper abdomen
- Fever 4,121
- Feeling sick to your stomach 3,695
- Loose stools 3,536
- Feeling tired 3,152
- Discomfort 3,121
- High blood sugar 3,038
- Feeling sick to your stomach 2,020
- Weight loss 1,536
- Loose stools 1,282
- Feeling lightheaded 1,201
Coadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole.
Oral diabetes medicines like glyburide may increase your risk of heart problems, compared to treatment with diet alone or diet plus insulin. Talk to your doctor about the risks and benefits of taking glyburide.
Tell your doctor if you are pregnant or plan to become pregnant. Fluconazole may not be safe for your baby. Talk to your doctor about breastfeeding while taking fluconazole.
Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if glyburide will harm your unborn baby. Talk to your doctor if you are breastfeeding.
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How to Read This fluconazole vs glyburide Comparison
fluconazole is classified in the Azole Antifungal drug class, while glyburide sits within the Sulfonylurea class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluconazole has 17,625 submissions while glyburide has 9,077. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to fluconazole slows down how the body breaks down glyburide, which causes the diabetes medicine to stay in the blood longer. this can lead to blood sugar levels dropping too low.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between fluconazole and glyburide - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.