Eprosartan and Nifedipine Interaction
Drug interaction information between Eprosartan and Nifedipine.
Eprosartan and Nifedipine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Eprosartan and Nifedipine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These two blood pressure medicines do not have a negative effect on each other when taken together.
What To Do
You can safely take these medications together as prescribed by your doctor.
FDA Label Information
have been safely used concomitantly with sustained-release calcium channel blockers (sustained-release nifedipine) with no clinically significant adverse interactions.
Eprosartan Also Interacts With
- Aliskiren major
- Hydrochlorothiazide minor
- Warfarin minor
- Ketoconazole minor
- Fluconazole minor
Nifedipine Also Interacts With
- Theophylline major
- Phenytoin moderate
- Nirmatrelvir/Ritonavir moderate
- Tacrolimus Topical moderate
- Fluoxetine minor
Frequently Asked Questions
Can I take Eprosartan and Nifedipine together?
This is a minor interaction. You can safely take these medications together as prescribed by your doctor.
How serious is the interaction between Eprosartan and Nifedipine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Eprosartan and Nifedipine interact?
These two blood pressure medicines do not have a negative effect on each other when taken together.
Understanding the Eprosartan and Nifedipine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Eprosartan belongs to the Angiotensin II Receptor Blocker (ARB) class and Nifedipine belongs to the Calcium Channel Blocker class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These two blood pressure medicines do not have a negative effect on each other when taken together. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Eprosartan has 9 total documented interactions on file in this dataset, and Nifedipine has 26. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You can safely take these medications together as prescribed by your doctor. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Eprosartan or Nifedipine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.