Eprosartan and Ketoconazole Interaction
Drug interaction information between Eprosartan and Ketoconazole.
Eprosartan and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Eprosartan and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole blocks certain liver proteins, but eprosartan is not processed by those proteins, so its levels do not change.
FDA Label Information
Eprosartan is not metabolized by the cytochrome P450 system; eprosartan steady-state concentrations were not affected by concomitant administration of ketoconazole or fluconazole, potent inhibitors of CYP3A and 2C9, respectively. Because eprosartan is not metabolized by the cytochrome P450 system, inhibitors of CYP450 enzyme would not be expected to affect its metabolism, and ketoconazole and fluconazole, potent inhibitors of CYP3A and 2C9, respectively, have been shown to have no effect on eprosartan pharmacokinetics.
Eprosartan Also Interacts With
- Aliskiren major
- Hydrochlorothiazide minor
- Warfarin minor
- Nifedipine minor
- Fluconazole minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Eprosartan + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Eprosartan's 9. In the minor band specifically: Eprosartan has 8 (also Hydrochlorothiazide, Warfarin, Nifedipine, Fluconazole); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Eprosartan and Ketoconazole?
Ketoconazole blocks certain liver proteins, but eprosartan is not processed by those proteins, so its levels do not change.
Ketoconazole carries more major-labeled pairs than Eprosartan
SPL source-record counts only. This page's band is minor · classes on file: Eprosartan (Angiotensin II Receptor Blocker (ARB)); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Eprosartan's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 8 minor · 9 total
- Other minor peers for Eprosartan
- Hydrochlorothiazide
- Warfarin
- Nifedipine
- Fluconazole
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.