Eprosartan and Ketoconazole Interaction
Drug interaction information between Eprosartan and Ketoconazole.
Eprosartan and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Eprosartan and Ketoconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Ketoconazole blocks certain liver proteins, but eprosartan is not processed by those proteins, so its levels do not change.
What To Do
No special precautions are needed when taking these two drugs together.
FDA Label Information
Eprosartan is not metabolized by the cytochrome P450 system; eprosartan steady-state concentrations were not affected by concomitant administration of ketoconazole or fluconazole, potent inhibitors of CYP3A and 2C9, respectively. Because eprosartan is not metabolized by the cytochrome P450 system, inhibitors of CYP450 enzyme would not be expected to affect its metabolism, and ketoconazole and fluconazole, potent inhibitors of CYP3A and 2C9, respectively, have been shown to have no effect on eprosartan pharmacokinetics.
Eprosartan Also Interacts With
- Aliskiren major
- Hydrochlorothiazide minor
- Warfarin minor
- Nifedipine minor
- Fluconazole minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
Can I take Eprosartan and Ketoconazole together?
This is a minor interaction. No special precautions are needed when taking these two drugs together.
How serious is the interaction between Eprosartan and Ketoconazole?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Eprosartan and Ketoconazole interact?
Ketoconazole blocks certain liver proteins, but eprosartan is not processed by those proteins, so its levels do not change.
Understanding the Eprosartan and Ketoconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Eprosartan belongs to the Angiotensin II Receptor Blocker (ARB) class and Ketoconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Ketoconazole blocks certain liver proteins, but eprosartan is not processed by those proteins, so its levels do not change. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Eprosartan has 9 total documented interactions on file in this dataset, and Ketoconazole has 113. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No special precautions are needed when taking these two drugs together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Eprosartan or Ketoconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.