Eprosartan and Hydrochlorothiazide Interaction
Drug interaction information between Eprosartan and Hydrochlorothiazide.
Eprosartan and Hydrochlorothiazide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Eprosartan and Hydrochlorothiazide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs work together to lower blood pressure and have been shown to be safe when used at the same time.
FDA Label Information
or 800 mg q.d.) doses have been safely used concomitantly with a thiazide diuretic (hydrochlorothiazide).
Eprosartan Also Interacts With
- Aliskiren major
- Warfarin minor
- Nifedipine minor
- Ketoconazole minor
- Fluconazole minor
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Lisinopril major
- Olmesartan moderate
- Losartan minor
Frequently Asked Questions
What SPL severity band is on file for Eprosartan + Hydrochlorothiazide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydrochlorothiazide has 31 labeled pairs on file vs Eprosartan's 9. In the minor band specifically: Eprosartan has 8 (also Warfarin, Nifedipine, Ketoconazole, Fluconazole); Hydrochlorothiazide has 27 (also Losartan, Spironolactone, Propranolol, Lithium).
What mechanism field is on file for Eprosartan and Hydrochlorothiazide?
These two drugs work together to lower blood pressure and have been shown to be safe when used at the same time.
Hydrochlorothiazide carries more major-labeled pairs than Eprosartan
SPL source-record counts only. This page's band is minor · classes on file: Eprosartan (Angiotensin II Receptor Blocker (ARB)); Hydrochlorothiazide (Thiazide Diuretic).
Hydrochlorothiazide has 3 major-labeled pairs vs Eprosartan's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 8 minor · 9 total
- Other minor peers for Eprosartan
- Warfarin
- Nifedipine
- Ketoconazole
- Fluconazole
3 major · 1 moderate · 27 minor · 31 total
- Other minor peers for Hydrochlorothiazide
- Losartan
- Spironolactone
- Propranolol
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.