Insulin Aspart and Fluoxetine Interaction
Drug interaction information between Insulin Aspart and Fluoxetine.
Insulin Aspart and Fluoxetine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Insulin Aspart and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine can make insulin work more strongly, which may cause your blood sugar to drop to a level that is too low.
FDA Label Information
Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics. • Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and...
Insulin Aspart Also Interacts With
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
- Olanzapine minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Insulin Aspart + Fluoxetine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Insulin Aspart's 11. In the moderate band specifically: Insulin Aspart has 3 (also Pramlintide, Octreotide); Fluoxetine has 19 (also Alprazolam, Diazepam, Carbamazepine, Haloperidol).
What mechanism field is on file for Insulin Aspart and Fluoxetine?
Fluoxetine can make insulin work more strongly, which may cause your blood sugar to drop to a level that is too low.
Fluoxetine carries more major-labeled pairs than Insulin Aspart
SPL source-record counts only. This page's band is moderate · classes on file: Insulin Aspart (Rapid-Acting Insulin); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Insulin Aspart's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 8 minor · 11 total
- Other moderate peers for Insulin Aspart
- Pramlintide
- Octreotide
6 major · 19 moderate · 43 minor · 68 total
- Other moderate peers for Fluoxetine
- Alprazolam
- Diazepam
- Carbamazepine
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.