Glecaprevir/Pibrentasvir and Ethinyl Estradiol Interaction
Drug interaction information between Glecaprevir/Pibrentasvir and Ethinyl Estradiol.
Glecaprevir/Pibrentasvir and Ethinyl Estradiol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Glecaprevir/Pibrentasvir and Ethinyl Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs can lead to an increase in liver enzymes, which may indicate liver damage. Because of this risk, the two drugs should not be used together.
FDA Label Information
Co-administration of Iclevia and glecaprevir/pibrentasvir is not recommended due to potential for ALT elevations.
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Darunavir moderate
Ethinyl Estradiol Also Interacts With
- Atorvastatin minor
- Rosuvastatin minor
- Estradiol minor
- Lamotrigine minor
- Topiramate minor
Frequently Asked Questions
What SPL severity band is on file for Glecaprevir/Pibrentasvir + Ethinyl Estradiol/Norgestimate?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glecaprevir/Pibrentasvir has 38 labeled pairs on file vs Ethinyl Estradiol's 30. In the moderate band specifically: Glecaprevir/Pibrentasvir has 9 (also Cyclosporine, Darunavir, Estradiol, Ethinyl Estradiol); Ethinyl Estradiol has 1.
What mechanism field is on file for Glecaprevir/Pibrentasvir and Ethinyl Estradiol/Norgestimate?
Combining these drugs can lead to an increase in liver enzymes, which may indicate liver damage. Because of this risk, the two drugs should not be used together.
Glecaprevir/Pibrentasvir carries more major-labeled pairs than Ethinyl Estradiol
SPL source-record counts only. This page's band is moderate · classes on file: Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)); Ethinyl Estradiol (Combined Oral Contraceptive).
Glecaprevir/Pibrentasvir has 3 major-labeled pairs vs Ethinyl Estradiol's 0. This page itself is in the moderate band, not the major band.
3 major · 9 moderate · 26 minor · 38 total
- Other moderate peers for Glecaprevir/Pibrentasvir
- Cyclosporine
- Darunavir
- Estradiol
- Ethinyl Estradiol
0 major · 1 moderate · 29 minor · 30 total
Ethinyl Estradiol has no other moderate-band peer in this dataset besides Glecaprevir/Pibrentasvir.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.