estradiol vs gabapentin
Side-by-side comparison of estradiol and gabapentin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Oral Contraceptive Based on AUC and half-life, multiple-dose pharmacokinetic profiles of norethindrone and ethinyl estradiol following administration of tablets containing 2.5 mg of norethindrone acetate and 50 mcg of ethinyl estradiol were similar with and without coadministration of gabapentin (400 mg three times a day; N=13).
Recommendation: No special dose changes are usually needed when taking these two medications together.
Estrace, Vivelle-Dot
Neurontin, Gralise
Iclevia is a birth control pill. It contains two hormones, a progestin and an estrogen, that work together to prevent pregnancy.
Gabapentin is a medicine that can treat nerve pain and seizures. It works by calming overactive nerves in the body.
Iclevia is used by women who can get pregnant to prevent pregnancy. It contains two types of hormones. These hormones stop you from releasing an egg and also change the lining of your uterus, which prevents pregnancy.
Gabapentin is used to manage nerve pain after shingles in adults. This is called postherpetic neuralgia. It is also used with other medicines to treat partial seizures in adults and children ages 3 and older who have epilepsy.
Iclevia contains two hormones: levonorgestrel (a progestin) and ethinyl estradiol (an estrogen). These hormones prevent pregnancy by stopping ovulation (the release of an egg from the ovary). They also change the lining of the uterus to prevent a fertilized egg from implanting.
Gabapentin affects how nerves send signals to the brain. It is thought to work by decreasing the activity of overexcited nerve cells. This can reduce pain and prevent seizures.
- • Headache
- • Heavy menstrual bleeding
- • Nausea
- • Painful periods
- • Acne
- • Dizziness
- • Sleepiness
- • Swelling in arms and legs
- • Uncoordinated movements
- • Tiredness
- The product did not stick properly 5,172
- Headache 5,035
- Nausea 4,752
- Tiredness 4,511
- Pain 3,478
- Tiredness 24,395
- Feeling sick to your stomach 21,942
- Aches and discomfort 20,748
- Loose or watery stools 17,456
- Pain in your head 17,287
Cigarette smoking increases your risk of serious heart problems from birth control pills. This risk is higher if you are over 35 and smoke more cigarettes. You should not take Iclevia if you are over 35 and smoke.
This medicine can cause a severe allergic reaction with fever, rash, and organ problems. Stop taking gabapentin and get medical help right away if you have trouble breathing or swelling of your face, lips, tongue, or throat. Do not drive or operate heavy machinery until you know how gabapentin affects you. Do not stop taking gabapentin suddenly, as this may increase seizures. Gabapentin may cause suicidal thoughts or actions. Watch for changes in mood or behavior. Using gabapentin with opioid medicines can cause very slow breathing, sedation, and death. Children ages 3 to 12 may have new or worsening behavior problems.
Do not use Iclevia if you are pregnant. If you become pregnant while taking Iclevia, stop taking it right away. Iclevia can reduce milk production, so you may want to use a different birth control method while breastfeeding.
Gabapentin may cause harm to an unborn baby based on animal studies. If you are pregnant or plan to become pregnant, talk to your doctor. Gabapentin passes into breast milk. The effects on a nursing baby are not known.
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How to Read This estradiol vs gabapentin Comparison
estradiol is classified in the Estrogen Hormone drug class, while gabapentin sits within the Anticonvulsant / Nerve Pain Agent class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, estradiol has 22,948 submissions while gabapentin has 101,828. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to based on clinical studies, gabapentin does not change how the body processes or reacts to birth control hormones like estradiol. there is no significant interaction between these two drugs.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between estradiol and gabapentin - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.