Fluoxetine and Clonazepam Interaction
Drug interaction information between Fluoxetine and Clonazepam.
Fluoxetine and Clonazepam have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Fluoxetine and Clonazepam. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Fluoxetine does not interfere with how your body breaks down or uses clonazepam.
What To Do
These medications can generally be taken together without needing to change your dose.
FDA Label Information
The selective serotonin reuptake inhibitors sertraline (weak CYP3A4 inducer) and fluoxetine (CYP2D6 inhibitor), and the anti-epileptic drug felbamate (CYP2C19 inhibitor and CYP3A4 inducer) do not affect the pharmacokinetics of clonazepam.
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Clonazepam Also Interacts With
- Sertraline major
- Felbamate major
- Diazepam moderate
- Lamotrigine minor
- Fluconazole minor
Frequently Asked Questions
Can I take Fluoxetine and Clonazepam together?
This is a major interaction. These medications can generally be taken together without needing to change your dose.
How serious is the interaction between Fluoxetine and Clonazepam?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Fluoxetine and Clonazepam interact?
Fluoxetine does not interfere with how your body breaks down or uses clonazepam.
Understanding the Fluoxetine and Clonazepam Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Fluoxetine belongs to the Selective Serotonin Reuptake Inhibitor (SSRI) class and Clonazepam belongs to the Benzodiazepine class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Fluoxetine does not interfere with how your body breaks down or uses clonazepam. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Fluoxetine has 68 total documented interactions on file in this dataset, and Clonazepam has 14. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: These medications can generally be taken together without needing to change your dose. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Fluoxetine or Clonazepam based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.