felodipine vs spironolactone
Side-by-side comparison of felodipine and spironolactone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Other Concomitant Therapy In healthy subjects there were no clinically significant interactions when felodipine was given concomitantly with indomethacin or spironolactone.
Recommendation: No special changes are usually needed when taking these two drugs together. Continue taking your medications as prescribed.
Plendil
Aldactone
Felodipine is a drug that lowers your blood pressure. Lowering blood pressure reduces the risk of strokes and heart attacks.
Spironolactone is a medicine that helps remove extra fluid from your body and lower blood pressure. It also helps your heart work better if you have heart failure.
Felodipine treats high blood pressure (hypertension). Lowering your blood pressure helps prevent strokes and heart attacks. It's important to also manage other risk factors like cholesterol, diabetes, and smoking. You may need more than one medicine to control your blood pressure.
Spironolactone is used to treat heart failure by reducing fluid build-up and helping you live longer. It also treats high blood pressure, which can lower your chance of having a stroke or heart attack. This medicine can also manage fluid build-up caused by liver problems or a kidney problem called nephrotic syndrome. It can also treat a condition where your body makes too much of a hormone called aldosterone.
Felodipine is a calcium channel blocker. It works by relaxing and widening your blood vessels. This makes it easier for blood to flow, which lowers blood pressure.
Spironolactone belongs to a class of drugs called aldosterone antagonists. It works by blocking the effects of aldosterone, a hormone that causes your body to hold onto salt and water. By blocking aldosterone, spironolactone helps your body get rid of extra fluid and salt, which lowers blood pressure and reduces strain on the heart.
- • Swelling in your ankles or feet
- • Headache
- • Flushing (redness of face)
- • Feeling tired
- • Breast enlargement in men
- • Dizziness
- • Headache
- Feeling tired 1,050
- Difficulty breathing 953
- Feeling lightheaded 946
- Loose stools 846
- Feeling sick to your stomach 846
- Difficulty breathing 10,389
- Tiredness 8,179
- Feeling sick to your stomach 7,818
- Loose stools 7,416
- Sudden kidney damage 6,785
If you take certain medicines like ketoconazole, itraconazole, or erythromycin, talk to your doctor. These drugs can greatly increase the amount of felodipine in your blood, leading to unwanted effects. Also, if you take anticonvulsants like phenytoin, carbamazepine, or phenobarbital, felodipine may not work as well.
Spironolactone can cause your potassium levels to get too high, which can be dangerous. Your doctor will check your potassium levels regularly, especially if you have kidney problems or are taking other medicines that can raise potassium. This medicine can also cause low blood pressure or make kidney problems worse. Tell your doctor if you have side effects.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if felodipine will harm your unborn baby. Talk to your doctor about breastfeeding while taking felodipine.
Spironolactone may affect the sex organs of a baby boy if taken during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if spironolactone passes into breast milk, so talk to your doctor about the best way to feed your baby if you are taking this medicine.
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How to Read This felodipine vs spironolactone Comparison
felodipine is classified in the Calcium Channel Blocker drug class, while spironolactone sits within the Potassium-Sparing Diuretic / Aldosterone Antagonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, felodipine has 4,641 submissions while spironolactone has 40,587. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to there is no significant interaction between these two drugs. they do not interfere with how each other works in the body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between felodipine and spironolactone - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.