aripiprazole vs famotidine
Side-by-side comparison of aripiprazole and famotidine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.2 Drugs Having No Clinically Important Interactions with Aripiprazole Based on pharmacokinetic studies, no dosage adjustment of aripiprazole is required when administered concomitantly with famotidine, valproate, lithium, lorazepam.
Recommendation: No dosage changes are needed when taking these medications together.
Abilify
Pepcid
Aripiprazole (Abilify) is a medicine used to treat certain mental disorders and mood problems. It can help to improve your mood, thinking, and behavior.
Famotidine (Pepcid) reduces stomach acid. It is used to treat ulcers, heartburn, and acid reflux.
Aripiprazole is used to treat schizophrenia in adults and teens. It also treats irritability in children with autism. Additionally, it can treat Tourette's disorder.
This medicine treats active duodenal ulcers and active gastric ulcers. It also treats heartburn (nonerosive GERD) and erosive esophagitis (damage to the esophagus from acid reflux). Famotidine can also treat conditions where the stomach makes too much acid, like Zollinger-Ellison syndrome. It can also lower the risk of duodenal ulcers coming back.
Aripiprazole works by affecting the levels of certain chemicals in the brain. These chemicals, like dopamine and serotonin, can affect mood and behavior. By balancing these chemicals, aripiprazole helps to reduce symptoms of mental health conditions.
Famotidine is an H2 receptor antagonist. This means it blocks histamine, a substance that tells your stomach to make acid. By blocking histamine, famotidine reduces the amount of acid your stomach produces.
- • Nausea
- • Vomiting
- • Constipation
- • Headache
- • Dizziness
- • Headache
- • Dizziness
- • Constipation
- • Diarrhea
- Gaining weight 7,698
- Feeling worried or nervous 4,995
- Feeling tired 4,188
- Thinking about suicide 3,991
- Feeling sad or hopeless 3,952
- Feeling sick to your stomach 7,259
- Feeling tired 6,866
- Long-term kidney problems 6,644
- Loose, watery stools 6,448
- Difficulty breathing 5,203
Aripiprazole may increase the risk of death in elderly patients who have psychosis related to dementia. It is not approved for this use. Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teens, and young adults. Watch closely for worsening mood or suicidal thoughts.
In elderly patients and those with kidney problems, famotidine can cause confusion, delirium, or hallucinations. If you are elderly or have kidney problems, your doctor may prescribe a lower dose. Famotidine can hide the symptoms of stomach cancer. If your symptoms don't improve, tell your doctor.
If you are pregnant or plan to become pregnant, talk to your doctor. Aripiprazole may cause withdrawal symptoms or other problems in newborns if taken during the third trimester. There is a pregnancy registry for women who take aripiprazole during pregnancy.
It is not known if famotidine will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Famotidine may pass into breast milk, but it's not expected to harm the baby. Talk to your doctor about breastfeeding while taking this medicine.
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How to Read This aripiprazole vs famotidine Comparison
aripiprazole is classified in the Atypical Antipsychotic drug class, while famotidine sits within the H2 Receptor Antagonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, aripiprazole has 24,824 submissions while famotidine has 32,420. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these two drugs do not significantly change how the body processes or removes each other.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between aripiprazole and famotidine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.