Ezetimibe/Simvastatin and Gemfibrozil Interaction
Drug interaction information between Ezetimibe/Simvastatin and Gemfibrozil.
Ezetimibe/Simvastatin and Gemfibrozil have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ezetimibe/Simvastatin and Gemfibrozil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can cause muscle problems on their own, and using them together significantly increases the risk of severe muscle breakdown.
FDA Label Information
Cyclosporine, Danazol, or Gemfibrozil Clinical Impact: The risk of myopathy and rhabdomyolysis is increased with concomitant use of cyclosporine, danazol, or gemfibrozil with VYTORIN. Gemfibrozil may cause myopathy when given alone. Intervention: Concomitant use of cyclosporine, danazol, or gemfibrozil with VYTORIN is contraindicated [see Contraindications (4) ] .
Ezetimibe/Simvastatin Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Gemfibrozil Also Interacts With
- Ezetimibe major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
- Eluxadoline moderate
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe/Simvastatin + Gemfibrozil?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ezetimibe/Simvastatin has 23 labeled pairs on file vs Gemfibrozil's 20. In the major band specifically: Ezetimibe/Simvastatin has 8 (also Amlodipine, Diltiazem, Verapamil, Cyclosporine); Gemfibrozil has 4 (also Ezetimibe, Repaglinide, Simvastatin).
What mechanism field is on file for Ezetimibe/Simvastatin and Gemfibrozil?
Both of these medications can cause muscle problems on their own, and using them together significantly increases the risk of severe muscle breakdown.
Ezetimibe/Simvastatin carries more major-labeled pairs than Gemfibrozil
SPL source-record counts only. This page's band is major · classes on file: Ezetimibe/Simvastatin (Cholesterol Absorption Inhibitor / Statin Combination); Gemfibrozil (Fibrate).
Ezetimibe/Simvastatin has 8 major-labeled pairs vs Gemfibrozil's 4.
8 major · 4 moderate · 11 minor · 23 total
- Other major peers for Ezetimibe/Simvastatin
- Amlodipine
- Diltiazem
- Verapamil
- Cyclosporine
4 major · 8 moderate · 8 minor · 20 total
- Other major peers for Gemfibrozil
- Ezetimibe
- Repaglinide
- Simvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.