Ezetimibe and Simvastatin Interaction
Drug interaction information between Ezetimibe and Simvastatin.
Ezetimibe and Simvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ezetimibe and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two cholesterol medicines together can increase the risk of muscle damage or weakness. This happens because both drugs can affect your muscles in similar ways.
FDA Label Information
7 DRUG INTERACTIONS Ezetimibe and S imvastatin See full prescribing information for details regarding concomitant use of ezetimibe and simvastatin tablets with other drugs or grapefruit juice that increase the risk of myopathy and rhabdomyolysis. ( 2.3 , 7.1 ) Cholestyramine : Combination decreases exposure of ezetimibe. ( 2.3 , 7.2 ) Coumarin Anticoagulants: Obtain INR before ezetimibe and simvastatin tablets initiation and monitor INR during ezetimibe and simvastatin tablets dosage initiation or adjustment.
Ezetimibe Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe + Simvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Ezetimibe's 25. In the moderate band specifically: Ezetimibe has 4 (also Daptomycin, Colchicine, Niacin); Simvastatin has 9 (also Daptomycin, Colchicine, Niacin, Bempedoic Acid).
What mechanism field is on file for Ezetimibe and Simvastatin?
Using these two cholesterol medicines together can increase the risk of muscle damage or weakness. This happens because both drugs can affect your muscles in similar ways.
Simvastatin carries more major-labeled pairs than Ezetimibe
SPL source-record counts only. This page's band is moderate · classes on file: Ezetimibe (Cholesterol Absorption Inhibitor); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Ezetimibe's 8. This page itself is in the moderate band, not the major band.
8 major · 4 moderate · 13 minor · 25 total
- Other moderate peers for Ezetimibe
- Daptomycin
- Colchicine
- Niacin
11 major · 9 moderate · 21 minor · 41 total
- Other moderate peers for Simvastatin
- Daptomycin
- Colchicine
- Niacin
- Bempedoic Acid
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.