etodolac vs hydrochlorothiazide
Side-by-side comparison of etodolac and hydrochlorothiazide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Diuretics Etodolac has no apparent pharmacokinetic interaction when administered with furosemide or hydrochlorothiazide.
Recommendation: You can usually take these together, but you should still have your blood pressure checked regularly.
Lodine
Microzide
Etodolac is a pain reliever and anti-inflammatory medicine. It helps reduce pain, swelling, and stiffness caused by arthritis and other conditions.
No summary available.
Etodolac treats the symptoms of osteoarthritis and rheumatoid arthritis. It can help with pain and swelling in your joints. Etodolac is also used for short-term relief of acute pain.
Information not available.
Etodolac is an NSAID, which stands for Nonsteroidal Anti-Inflammatory Drug. It works by reducing substances in the body that cause pain and inflammation. It can help to reduce fever as well.
Information not available.
- • Upset stomach
- • Constipation
- • Diarrhea
- • Gas
- • Heartburn
- • Dizziness
- • Headache
- • Cough
- • Fatigue
- Pain 350
- Feeling sick to your stomach 290
- Joint pain 284
- Tiredness 273
- Headache 239
- Tiredness 10,013
- Feeling sick to your stomach 9,706
- Loose stools 8,311
- Discomfort 7,665
- Difficulty breathing 7,584
NSAIDs like etodolac can increase your risk of heart attack or stroke, which can be fatal. This risk may happen early in treatment and increases with longer use. You should not take etodolac if you are having heart bypass surgery. NSAIDs also increase the risk of serious stomach problems like bleeding and ulcers, which can be fatal. Older adults are at higher risk for these stomach problems.
No specific warnings noted.
Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Etodolac may harm your unborn baby. It is not known if etodolac passes into breast milk.
No pregnancy information available.
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How to Read This etodolac vs hydrochlorothiazide Comparison
etodolac is classified in the Nonsteroidal Anti-Inflammatory Drug (NSAID) drug class, while hydrochlorothiazide sits within the Thiazide Diuretic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, etodolac has 1,436 submissions while hydrochlorothiazide has 43,279. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these drugs do not significantly change how the body absorbs or processes each other.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between etodolac and hydrochlorothiazide - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.