cyclosporine vs etodolac
Side-by-side comparison of cyclosporine and etodolac. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Cyclosporine, Digoxin, Methotrexate Etodolac, like other NSAIDs, through effects on renal prostaglandins, may cause changes in the elimination of these drugs leading to elevated serum levels of cyclosporine, digoxin, methotrexate, and increased toxicity. Nephrotoxicity associated with cyclosporine may also be enhanced.
Recommendation: Your doctor should monitor your kidney function and drug levels closely if you take these together. They may need to adjust your dose to prevent kidney damage.
Neoral, Sandimmune, Restasis
Lodine
Vevye eye drops contain cyclosporine. They help treat the signs and symptoms of dry eye disease.
Etodolac is a pain reliever and anti-inflammatory medicine. It helps reduce pain, swelling, and stiffness caused by arthritis and other conditions.
Vevye treats the signs and symptoms of dry eye disease. Dry eye can cause discomfort, stinging, and blurred vision. This medicine can help reduce these symptoms.
Etodolac treats the symptoms of osteoarthritis and rheumatoid arthritis. It can help with pain and swelling in your joints. Etodolac is also used for short-term relief of acute pain.
Vevye contains cyclosporine, which is an immunosuppressant. It works by decreasing inflammation in the eyes. This helps your eyes make more tears.
Etodolac is an NSAID, which stands for Nonsteroidal Anti-Inflammatory Drug. It works by reducing substances in the body that cause pain and inflammation. It can help to reduce fever as well.
- • Irritation where the drops are applied (8%)
- • Upset stomach
- • Constipation
- • Diarrhea
- • Gas
- • Heartburn
- Eye feels irritated 7,786
- Fever 4,066
- Eye ache 3,808
- Feeling sick to your stomach 3,623
- Loose stools 3,562
- Pain 350
- Feeling sick to your stomach 290
- Joint pain 284
- Tiredness 273
- Headache 239
To avoid eye injury or contamination, do not touch the bottle tip to your eye or any other surface. Do not use Vevye while wearing contact lenses. If you wear contacts, remove them before using the drops. You can put them back in 15 minutes after using Vevye.
NSAIDs like etodolac can increase your risk of heart attack or stroke, which can be fatal. This risk may happen early in treatment and increases with longer use. You should not take etodolac if you are having heart bypass surgery. NSAIDs also increase the risk of serious stomach problems like bleeding and ulcers, which can be fatal. Older adults are at higher risk for these stomach problems.
It is not known if Vevye will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Cyclosporine can pass into breast milk after being taken orally, but it is unknown if it passes into breast milk from eye drops. Talk to your doctor if you are breastfeeding.
Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Etodolac may harm your unborn baby. It is not known if etodolac passes into breast milk.
Also Compare, Nearby Drugs
Compare etodolac with
How to Read This cyclosporine vs etodolac Comparison
cyclosporine is classified in the Calcineurin Inhibitor (Immunosuppressant) drug class, while etodolac sits within the Nonsteroidal Anti-Inflammatory Drug (NSAID) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cyclosporine has 22,845 submissions while etodolac has 1,436. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to etodolac makes it harder for your kidneys to remove cyclosporine from your blood, which can lead to toxic levels. this combination can also increase the risk of damage to your kidneys.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between cyclosporine and etodolac - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.