Eprosartan and Fluconazole Interaction
Drug interaction information between Eprosartan and Fluconazole.
Eprosartan and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Eprosartan and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole blocks liver enzymes that break down some drugs, but eprosartan is not affected by these enzymes.
FDA Label Information
Eprosartan is not metabolized by the cytochrome P450 system; eprosartan steady-state concentrations were not affected by concomitant administration of ketoconazole or fluconazole, potent inhibitors of CYP3A and 2C9, respectively. Because eprosartan is not metabolized by the cytochrome P450 system, inhibitors of CYP450 enzyme would not be expected to affect its metabolism, and ketoconazole and fluconazole, potent inhibitors of CYP3A and 2C9, respectively, have been shown to have no effect on eprosartan pharmacokinetics.
Eprosartan Also Interacts With
- Aliskiren major
- Hydrochlorothiazide minor
- Warfarin minor
- Nifedipine minor
- Ketoconazole minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Eprosartan + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Eprosartan's 9. In the minor band specifically: Eprosartan has 8 (also Hydrochlorothiazide, Warfarin, Nifedipine, Ketoconazole); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Eprosartan and Fluconazole?
Fluconazole blocks liver enzymes that break down some drugs, but eprosartan is not affected by these enzymes.
Fluconazole carries more major-labeled pairs than Eprosartan
SPL source-record counts only. This page's band is minor · classes on file: Eprosartan (Angiotensin II Receptor Blocker (ARB)); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Eprosartan's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 8 minor · 9 total
- Other minor peers for Eprosartan
- Hydrochlorothiazide
- Warfarin
- Nifedipine
- Ketoconazole
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.