Empagliflozin and Zonisamide Interaction
Drug interaction information between Empagliflozin and Zonisamide.
Empagliflozin and Zonisamide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Empagliflozin and Zonisamide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Zonisamide can cause a buildup of acid in your blood by lowering bicarbonate levels. Taking it with this medicine may increase the risk of this chemical imbalance.
Empagliflozin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Metformin/Empagliflozin moderate
- Cimetidine moderate
Zonisamide Also Interacts With
- Alogliptin moderate
- Ertugliflozin moderate
- Topiramate moderate
- Carbamazepine minor
- Empagliflozin/Linagliptin minor
Frequently Asked Questions
What SPL severity band is on file for Empagliflozin + Zonisamide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Zonisamide has 13 labeled pairs on file vs Empagliflozin's 10. In the minor band specifically: Empagliflozin has 5 (also Topiramate, Lithium, Phenytoin, Empagliflozin/Linagliptin); Zonisamide has 10 (also Carbamazepine, Empagliflozin/Linagliptin, Linagliptin, Metformin).
What mechanism field is on file for Empagliflozin and Zonisamide?
Zonisamide can cause a buildup of acid in your blood by lowering bicarbonate levels. Taking it with this medicine may increase the risk of this chemical imbalance.
Zonisamide's labeled portfolio outnumbers Empagliflozin
SPL source-record counts only. This page's band is minor · classes on file: Empagliflozin (SGLT2 Inhibitor); Zonisamide (Anticonvulsant (Sulfonamide)).
0 major · 5 moderate · 5 minor · 10 total
- Other minor peers for Empagliflozin
- Topiramate
- Lithium
- Phenytoin
- Empagliflozin/Linagliptin
0 major · 3 moderate · 10 minor · 13 total
- Other minor peers for Zonisamide
- Carbamazepine
- Empagliflozin/Linagliptin
- Linagliptin
- Metformin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.