Empagliflozin and Lithium Interaction
Drug interaction information between Empagliflozin and Lithium.
Empagliflozin and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Empagliflozin and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Empagliflozin can cause your kidneys to remove lithium from your body more quickly, which lowers the amount of medicine in your blood.
FDA Label Information
Lithium Clinical Impact Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations. Intervention Monitor serum lithium concentration more frequently during SYNJARDY or SYNJARDY XR initiation and dosage changes.
Empagliflozin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Metformin/Empagliflozin moderate
- Cimetidine moderate
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Empagliflozin + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Empagliflozin's 10. In the minor band specifically: Empagliflozin has 5 (also Topiramate, Phenytoin, Zonisamide, Empagliflozin/Linagliptin); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Empagliflozin and Lithium?
Empagliflozin can cause your kidneys to remove lithium from your body more quickly, which lowers the amount of medicine in your blood.
Lithium carries more major-labeled pairs than Empagliflozin
SPL source-record counts only. This page's band is minor · classes on file: Empagliflozin (SGLT2 Inhibitor); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Empagliflozin's 0. This page itself is in the minor band, not the major band.
0 major · 5 moderate · 5 minor · 10 total
- Other minor peers for Empagliflozin
- Topiramate
- Phenytoin
- Zonisamide
- Empagliflozin/Linagliptin
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.