What the FDA labels say about taking them together
Empagliflozin and lithium
Empagliflozin's FDA label of January 30, 2026 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name empagliflozin. The empagliflozin label: “Lithium Clinical Impact Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations. Intervention Monitor serum lithium concentration more frequently during JARDIANCE initiation and …”
Check it at the source: the empagliflozin FDA label on DailyMed (effective January 30, 2026, Boehringer Ingelheim Pharmaceuticals, Inc.); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the empagliflozin label say about lithium?
Empagliflozin label, drug interactionsLithium Clinical Impact Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations. Intervention Monitor serum lithium concentration more frequently during JARDIANCE initiation and dosage changes.
Source: FDA drug label (Jardiance), Boehringer Ingelheim Pharmaceuticals, Inc., effective January 30, 2026 (SPL set faf3dd6a-9cd0-39c2-0d2e-232cb3f67565), via openFDA; the full label on DailyMed
What does the lithium label say about empagliflozin?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name empagliflozin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Empagliflozin | Lithium | |
|---|---|---|
| Labeled for | Heart failure, Type 2 diabetes, Chronic kidney disease | Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $11.19 per tablet 10 mg tablet | $0.104 per capsule 300 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once