Empagliflozin and Topiramate Interaction
Drug interaction information between Empagliflozin and Topiramate.
Empagliflozin and Topiramate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Empagliflozin and Topiramate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Topiramate can cause a chemical imbalance that makes your blood too acidic.
Empagliflozin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Metformin/Empagliflozin moderate
- Cimetidine moderate
Topiramate Also Interacts With
- Zonisamide moderate
- Alogliptin moderate
- Ertugliflozin moderate
- Hydrochlorothiazide minor
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Empagliflozin + Topiramate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Topiramate has 30 labeled pairs on file vs Empagliflozin's 10. In the minor band specifically: Empagliflozin has 5 (also Lithium, Phenytoin, Zonisamide, Empagliflozin/Linagliptin); Topiramate has 27 (also Hydrochlorothiazide, Amitriptyline, Pioglitazone, Carbamazepine).
What mechanism field is on file for Empagliflozin and Topiramate?
Topiramate can cause a chemical imbalance that makes your blood too acidic.
Topiramate's labeled portfolio outnumbers Empagliflozin
SPL source-record counts only. This page's band is minor · classes on file: Empagliflozin (SGLT2 Inhibitor); Topiramate (Anticonvulsant).
0 major · 5 moderate · 5 minor · 10 total
- Other minor peers for Empagliflozin
- Lithium
- Phenytoin
- Zonisamide
- Empagliflozin/Linagliptin
0 major · 3 moderate · 27 minor · 30 total
- Other minor peers for Topiramate
- Hydrochlorothiazide
- Amitriptyline
- Pioglitazone
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.