Empagliflozin and Ranolazine Interaction
Drug interaction information between Empagliflozin and Ranolazine.
Empagliflozin and Ranolazine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Empagliflozin and Ranolazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ranolazine interferes with how the kidneys clear metformin from your system. This can lead to higher levels of metformin in your blood and a higher risk of a dangerous acid buildup.
FDA Label Information
Drugs that Reduce Metformin Clearance Clinical Impact Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) could increase systemic exposure to metformin and may increase the risk for lactic acidosis [see Clinical Pharmacology (12.3) ] .
Empagliflozin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Metformin/Empagliflozin moderate
- Cimetidine moderate
- Topiramate minor
Ranolazine Also Interacts With
- Ketoconazole major
- Carbamazepine major
- Clarithromycin major
- Rifampin major
- Phenytoin major
Frequently Asked Questions
What SPL severity band is on file for Empagliflozin + Ranolazine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ranolazine has 31 labeled pairs on file vs Empagliflozin's 10. In the moderate band specifically: Empagliflozin has 5 (also Metformin, Dolutegravir, Metformin/Empagliflozin, Cimetidine); Ranolazine has 7 (also Empagliflozin/Linagliptin, Ertugliflozin, Linagliptin, Lovastatin).
What mechanism field is on file for Empagliflozin and Ranolazine?
Ranolazine interferes with how the kidneys clear metformin from your system. This can lead to higher levels of metformin in your blood and a higher risk of a dangerous acid buildup.
Ranolazine carries more major-labeled pairs than Empagliflozin
SPL source-record counts only. This page's band is moderate · classes on file: Empagliflozin (SGLT2 Inhibitor); Ranolazine (Late Sodium Current Inhibitor (Antianginal)).
Ranolazine has 12 major-labeled pairs vs Empagliflozin's 0. This page itself is in the moderate band, not the major band.
0 major · 5 moderate · 5 minor · 10 total
- Other moderate peers for Empagliflozin
- Metformin
- Dolutegravir
- Metformin/Empagliflozin
- Cimetidine
12 major · 7 moderate · 12 minor · 31 total
- Other moderate peers for Ranolazine
- Empagliflozin/Linagliptin
- Ertugliflozin
- Linagliptin
- Lovastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.