Duloxetine and Aspirin Interaction
Drug interaction information between Duloxetine and Aspirin.
Duloxetine and Aspirin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Duloxetine and Aspirin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these medicines can make it harder for your blood to clot, which raises your risk of having a serious stomach bleed.
What To Do
Use caution when taking these together and tell your doctor immediately if you notice unusual bruising or bleeding.
FDA Label Information
7.4 Drugs that Interfere with Hemostasis (e.g., NSAIDs, Aspirin, and Warfarin) Serotonin release by platelets plays an important role in hemostasis. Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding.
Duloxetine Also Interacts With
- Fluoxetine minor
- Famotidine minor
- Buspirone minor
- Paroxetine minor
- Lorazepam minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
Can I take Duloxetine and Aspirin together?
This is a moderate interaction. Use caution when taking these together and tell your doctor immediately if you notice unusual bruising or bleeding.
How serious is the interaction between Duloxetine and Aspirin?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Duloxetine and Aspirin interact?
Both of these medicines can make it harder for your blood to clot, which raises your risk of having a serious stomach bleed.
Understanding the Duloxetine and Aspirin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Duloxetine belongs to the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) class and Aspirin belongs to the Antiplatelet / NSAID class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these medicines can make it harder for your blood to clot, which raises your risk of having a serious stomach bleed. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Duloxetine has 18 total documented interactions on file in this dataset, and Aspirin has 47. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Use caution when taking these together and tell your doctor immediately if you notice unusual bruising or bleeding. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Duloxetine or Aspirin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.