What the FDA labels say about taking them together
Aspirin and duloxetine
Duloxetine's FDA label of May 14, 2024 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name duloxetine. The duloxetine label: “Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin, and other anti-coagulants may add to this risk.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the duloxetine FDA label on DailyMed (effective May 14, 2024, SUN PHARMACEUTICAL INDUSTRIES, INC.).
What does the aspirin label say about duloxetine?
Aspirin's label (effective September 9, 2025) does not name duloxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the duloxetine label say about aspirin?
Duloxetine label, drug interactionsExamples NSAIDs, aspirin, warfarin Inhibitors of CYP2D6 Clinical Impact Concomitant use of duloxetine with CYP2D6 inhibitors increase AUC of duloxetine. Greater degrees of inhibition are expected with higher doses of CYP2D6 inhibitors. Intervention Exercise caution when co-administering duloxetine delayed-release capsules and potent CYP2D6 inhibitors [see Warnings and Precautions (5.12), Clinical Pharmacology (12.3)].
Duloxetine label, warnings and precautionsConcomitant use of aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), warfarin, and other anti-coagulants may add to this risk.
Source: FDA drug label (Duloxetine, NDA219131), Almatica Pharma LLC, effective March 2, 2026 (SPL set bb2ca3bf-983c-1e4a-a91d-dc7dee66d741), via openFDA
Source: FDA drug label (DRIZALMA SPRINKLE), SUN PHARMACEUTICAL INDUSTRIES, INC., effective May 14, 2024 (SPL set b41423b8-dfec-4d79-ba3c-e43a87803d85), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Duloxetine | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Depression, Anxiety, Nerve pain and fibromyalgia, Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.102 per capsule 30 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once