drospirenone/ethinyl estradiol vs tizanidine
Side-by-side comparison of drospirenone/ethinyl estradiol and tizanidine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
COCs Increasing the Plasma Concentrations of CYP450 Enzymes In clinical studies, administration of a hormonal contraceptive containing EE did not lead to any increase or only to a weak increase in plasma concentrations of CYP3A4 substrates (e.g., midazolam) while plasma concentrations of CYP2C19 substrates (e.g., omeprazole and voriconazole) and CYP1A2 substrates (e.g., theophylline and tizanidine) can have a weak or moderate increase.
Recommendation: Your doctor should monitor you closely for increased side effects like sleepiness or low blood pressure.
Yaz, Yasmin
Zanaflex
This medicine contains drospirenone and ethinyl estradiol, which are hormones that prevent pregnancy. It also contains folate to help raise folate levels.
Tizanidine is a muscle relaxant. It is used to treat spasticity, which is when your muscles are tight or stiff.
This medicine can prevent pregnancy. It can also treat symptoms of premenstrual dysphoric disorder (PMDD) if you also want birth control. This medicine can also treat moderate acne in women at least 14 years old who also want birth control.
Tizanidine is used to treat spasticity in adults. Spasticity is a condition where your muscles become stiff or tight. This medicine helps to relax your muscles and reduce the stiffness. It can help you move and feel more comfortable.
This medicine prevents pregnancy by stopping ovulation (the release of an egg from the ovary). It also changes the lining of the uterus, making it harder for a fertilized egg to implant. The folate helps increase folate levels in the body.
Tizanidine works by affecting certain chemicals in your brain. It is an alpha-2 adrenergic agonist. This action helps to reduce muscle spasms and tightness.
- • Headache or migraine
- • Irregular periods
- • Nausea or vomiting
- • Breast pain or tenderness
- • Dry mouth
- • Sleepiness
- • Weakness
- • Dizziness
- Pain 13,037
- Injury 10,860
- Blood clot in the lungs 9,316
- Blood clot in a deep vein 8,390
- Anxiety 6,996
- Tiredness 1,693
- Aches 1,615
- Feeling sick to your stomach 1,530
- Falling down 1,318
- Head pain 1,289
Cigarette smoking increases your risk of serious heart problems when using birth control pills. This risk is higher if you are over 35 and smoke. Women over 35 who smoke should not use this medicine.
Tizanidine can cause low blood pressure, liver problems, and hallucinations. It can also make you very sleepy, especially if you drink alcohol or take other medicines that cause sleepiness. Your doctor should check your liver function before you start taking tizanidine and one month after you reach your highest dose. Do not stop taking tizanidine suddenly, as this can cause withdrawal symptoms.
Do not use this medicine if you are pregnant. This medicine can reduce milk production while breastfeeding. If possible, use other birth control methods until you stop breastfeeding.
Tizanidine may harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if tizanidine passes into breast milk, so talk to your doctor if you are breastfeeding.
Also Compare, Nearby Drugs
How to Read This drospirenone/ethinyl estradiol vs tizanidine Comparison
drospirenone/ethinyl estradiol is classified in the Combined Oral Contraceptive drug class, while tizanidine sits within the Central Alpha-2 Agonist (Muscle Relaxant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, drospirenone/ethinyl estradiol has 48,599 submissions while tizanidine has 7,445. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to the birth control pill interferes with the way your body clears tizanidine from your system. this can lead to higher levels of the drug in your body, which may increase side effects.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between drospirenone/ethinyl estradiol and tizanidine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.