Doxycycline and Ethinyl Estradiol Interaction
Drug interaction information between Doxycycline and Ethinyl Estradiol.
Doxycycline and Ethinyl Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Doxycycline and Ethinyl Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Doxycycline does not change the levels of birth control hormones in your blood.
FDA Label Information
The serum concentrations of etonogestrel and ethinyl estradiol were not affected by concomitant administration of oral amoxicillin or doxycycline in standard dosages during 10 days of antibiotic treatment.
Doxycycline Also Interacts With
- Tetracycline moderate
- Rifampin moderate
- Carbamazepine minor
- Bismuth Subsalicylate minor
- Phenytoin minor
Ethinyl Estradiol Also Interacts With
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Amoxicillin minor
- Estradiol minor
- Lamotrigine minor
Frequently Asked Questions
What SPL severity band is on file for Doxycycline + Ethinyl Estradiol/Etonogestrel?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ethinyl Estradiol has 28 labeled pairs on file vs Doxycycline's 9. In the minor band specifically: Doxycycline has 7 (also Carbamazepine, Bismuth Subsalicylate, Phenytoin, Doxycycline Hyclate); Ethinyl Estradiol has 27 (also Atorvastatin, Amoxicillin, Estradiol, Lamotrigine).
What mechanism field is on file for Doxycycline and Ethinyl Estradiol/Etonogestrel?
Doxycycline does not change the levels of birth control hormones in your blood.
Ethinyl Estradiol's labeled portfolio outnumbers Doxycycline
SPL source-record counts only. This page's band is minor · classes on file: Doxycycline (Tetracycline Antibiotic); Ethinyl Estradiol (Vaginal Contraceptive Ring).
0 major · 2 moderate · 7 minor · 9 total
- Other minor peers for Doxycycline
- Carbamazepine
- Bismuth Subsalicylate
- Phenytoin
- Doxycycline Hyclate
0 major · 1 moderate · 27 minor · 28 total
- Other minor peers for Ethinyl Estradiol
- Atorvastatin
- Amoxicillin
- Estradiol
- Lamotrigine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.