Ethinyl Estradiol and Lamotrigine Interaction
Drug interaction information between Ethinyl Estradiol and Lamotrigine.
Ethinyl Estradiol and Lamotrigine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ethinyl Estradiol and Lamotrigine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
The birth control ring causes your body to process and remove the seizure medicine more quickly.
FDA Label Information
A significant decrease in the plasma concentrations of lamotrigine has been shown, likely due to induction of lamotrigine glucuronidation. This may reduce seizure control; therefore, dosage adjustments of lamotrigine may be necessary.
Ethinyl Estradiol Also Interacts With
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Amoxicillin minor
- Estradiol minor
- Topiramate minor
Lamotrigine Also Interacts With
- Dofetilide moderate
- Desmopressin moderate
- Valproate minor
- Carbamazepine minor
- Rifampin minor
Frequently Asked Questions
What SPL severity band is on file for Ethinyl Estradiol/Etonogestrel + Lamotrigine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ethinyl Estradiol has 28 labeled pairs on file vs Lamotrigine's 24. In the minor band specifically: Ethinyl Estradiol has 27 (also Atorvastatin, Amoxicillin, Estradiol, Topiramate); Lamotrigine has 22 (also Valproate, Carbamazepine, Rifampin, Phenytoin).
What mechanism field is on file for Ethinyl Estradiol/Etonogestrel and Lamotrigine?
The birth control ring causes your body to process and remove the seizure medicine more quickly.
Ethinyl Estradiol's labeled portfolio outnumbers Lamotrigine
SPL source-record counts only. This page's band is minor · classes on file: Ethinyl Estradiol (Vaginal Contraceptive Ring); Lamotrigine (Anticonvulsant).
0 major · 1 moderate · 27 minor · 28 total
- Other minor peers for Ethinyl Estradiol
- Atorvastatin
- Amoxicillin
- Estradiol
- Topiramate
0 major · 2 moderate · 22 minor · 24 total
- Other minor peers for Lamotrigine
- Valproate
- Carbamazepine
- Rifampin
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.