Ethinyl Estradiol and Atorvastatin Interaction
Drug interaction information between Ethinyl Estradiol and Atorvastatin.
Ethinyl Estradiol and Atorvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ethinyl Estradiol and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Atorvastatin can raise the levels of birth control hormones in your blood.
FDA Label Information
Substances increasing the plasma concentrations of CHCs Co-administration of atorvastatin and certain CHCs containing ethinyl estradiol increase AUC values for ethinyl estradiol by approximately 20-25%.
Ethinyl Estradiol Also Interacts With
- Glecaprevir/Pibrentasvir moderate
- Amoxicillin minor
- Estradiol minor
- Lamotrigine minor
- Topiramate minor
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Ethinyl Estradiol/Etonogestrel + Atorvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Atorvastatin has 36 labeled pairs on file vs Ethinyl Estradiol's 28. In the minor band specifically: Ethinyl Estradiol has 27 (also Amoxicillin, Estradiol, Lamotrigine, Topiramate); Atorvastatin has 25 (also Estradiol, Norethindrone, Ketoconazole, Erythromycin).
What mechanism field is on file for Ethinyl Estradiol/Etonogestrel and Atorvastatin?
Atorvastatin can raise the levels of birth control hormones in your blood.
Atorvastatin carries more major-labeled pairs than Ethinyl Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Ethinyl Estradiol (Vaginal Contraceptive Ring); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Atorvastatin has 3 major-labeled pairs vs Ethinyl Estradiol's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 27 minor · 28 total
- Other minor peers for Ethinyl Estradiol
- Amoxicillin
- Estradiol
- Lamotrigine
- Topiramate
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Ketoconazole
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.