What the FDA labels say about taking them together
Ethinyl estradiol/etonogestrel and glecaprevir/pibrentasvir
Ethinyl estradiol/etonogestrel's FDA label of November 14, 2025 names glecaprevir/pibrentasvir in its drug interactions section; the glecaprevir/pibrentasvir label PlainMeds reads does not name ethinyl estradiol/etonogestrel. The ethinyl estradiol/etonogestrel label: “Concomitant use with some other HCV antiviral medicinal products, such as those containing glecaprevir/pibrentasvir, may increase the risk of ALT elevations.”
Check it at the source: the ethinyl estradiol/etonogestrel FDA label on DailyMed (effective November 14, 2025, Organon LLC); the glecaprevir/pibrentasvir FDA label on DailyMed (effective June 25, 2025, AbbVie Inc.).
What does the ethinyl estradiol/etonogestrel label say about glecaprevir/pibrentasvir?
Ethinyl estradiol/etonogestrel label, drug interactionsConcomitant use with some other HCV antiviral medicinal products, such as those containing glecaprevir/pibrentasvir, may increase the risk of ALT elevations [see Warnings and Precautions (5.4) ].
Source: FDA drug label (NuvaRing), Organon LLC, effective November 14, 2025 (SPL set 55eb60e3-6f4d-40a3-8ee6-e7fd2d0c7d97), via openFDA; the full label on DailyMed
What does the glecaprevir/pibrentasvir label say about ethinyl estradiol/etonogestrel?
Glecaprevir/pibrentasvir's label (effective June 25, 2025) does not name ethinyl estradiol/etonogestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Mavyret), AbbVie Inc., effective June 25, 2025 (SPL set 7bf99777-0401-9095-8645-16c6e907fcc0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/etonogestrel | Glecaprevir/pibrentasvir | |
|---|---|---|
| Labeled for | Birth control | Hepatitis C |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $46.35 per ring Etonogestrel-ee vaginal ring | $152.98 per tablet 100-40 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once