Ethinyl Estradiol and Glecaprevir/Pibrentasvir Interaction
Drug interaction information between Ethinyl Estradiol and Glecaprevir/Pibrentasvir.
Ethinyl Estradiol and Glecaprevir/Pibrentasvir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ethinyl Estradiol and Glecaprevir/Pibrentasvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medications at the same time can cause a rise in liver enzymes. This is often a sign that the liver is under stress or being irritated.
FDA Label Information
Concomitant use with some other HCV antiviral medicinal products, such as those containing glecaprevir/pibrentasvir, may increase the risk of ALT elevations [see Warnings and Precautions (5.4) ] .
Ethinyl Estradiol Also Interacts With
- Atorvastatin minor
- Amoxicillin minor
- Estradiol minor
- Lamotrigine minor
- Topiramate minor
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Darunavir moderate
Frequently Asked Questions
What SPL severity band is on file for Ethinyl Estradiol/Etonogestrel + Glecaprevir/Pibrentasvir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glecaprevir/Pibrentasvir has 38 labeled pairs on file vs Ethinyl Estradiol's 28. In the moderate band specifically: Ethinyl Estradiol has 1; Glecaprevir/Pibrentasvir has 9 (also Cyclosporine, Darunavir, Estradiol, Ethinyl Estradiol).
What mechanism field is on file for Ethinyl Estradiol/Etonogestrel and Glecaprevir/Pibrentasvir?
Taking these medications at the same time can cause a rise in liver enzymes. This is often a sign that the liver is under stress or being irritated.
Glecaprevir/Pibrentasvir carries more major-labeled pairs than Ethinyl Estradiol
SPL source-record counts only. This page's band is moderate · classes on file: Ethinyl Estradiol (Vaginal Contraceptive Ring); Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)).
Glecaprevir/Pibrentasvir has 3 major-labeled pairs vs Ethinyl Estradiol's 0. This page itself is in the moderate band, not the major band.
0 major · 1 moderate · 27 minor · 28 total
Ethinyl Estradiol has no other moderate-band peer in this dataset besides Glecaprevir/Pibrentasvir.
3 major · 9 moderate · 26 minor · 38 total
- Other moderate peers for Glecaprevir/Pibrentasvir
- Cyclosporine
- Darunavir
- Estradiol
- Ethinyl Estradiol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.