Dorzolamide/Timolol and Clonidine Interaction
Drug interaction information between Dorzolamide/Timolol and Clonidine.
Dorzolamide/Timolol and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dorzolamide/Timolol and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
The beta-blocker in the eye drops can make blood pressure rise even higher if you suddenly stop taking your clonidine medication.
FDA Label Information
7.8 Clonidine Oral beta-adrenergic blocking agents may exacerbate the rebound hypertension which can follow the withdrawal of clonidine.
Dorzolamide/Timolol Also Interacts With
- Timolol minor
- Dorzolamide minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Dorzolamide/Timolol + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Dorzolamide/Timolol's 3. In the minor band specifically: Dorzolamide/Timolol has 3 (also Timolol, Dorzolamide); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol).
What mechanism field is on file for Dorzolamide/Timolol and Clonidine?
The beta-blocker in the eye drops can make blood pressure rise even higher if you suddenly stop taking your clonidine medication.
Clonidine's labeled portfolio outnumbers Dorzolamide/Timolol
SPL source-record counts only. This page's band is minor · classes on file: Dorzolamide/Timolol (CAI / Beta-Blocker Combination (Ophthalmic)); Clonidine (Central Alpha-2 Agonist).
0 major · 0 moderate · 3 minor · 3 total
- Other minor peers for Dorzolamide/Timolol
- Timolol
- Dorzolamide
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.