Dorzolamide and Timolol Interaction
Drug interaction information between Dorzolamide and Timolol.
Dorzolamide and Timolol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dorzolamide and Timolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these drugs together can cause their effects to stack up, which may lead to more side effects throughout your body.
FDA Label Information
7 DRUG INTERACTIONS Potential additive effect of oral carbonic anhydrase inhibitor with dorzolamide hydrochloride and timolol maleate ophthalmic solution. ( 7.7 ) 7.1 Oral Carbonic Anhydrase Inhibitors There is a potential for an additive effect on the known systemic effects of carbonic anhydrase inhibition in patients receiving an oral carbonic anhydrase inhibitor and dorzolamide hydrochloride and timolol maleate ophthalmic solution. The concomitant administration of dorzolamide hydrochloride and timolol maleate ophthalmic solution and oral carbonic anhydrase inhibitors is not recommended.
Timolol Also Interacts With
- Clonidine minor
- Brimonidine/Timolol minor
- Darunavir minor
- Dorzolamide/Timolol minor
- Verapamil minor
Frequently Asked Questions
What SPL severity band is on file for Dorzolamide + Timolol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Timolol has 6 labeled pairs on file vs Dorzolamide's 2. In the moderate band specifically: Dorzolamide has 1; Timolol has 1.
What mechanism field is on file for Dorzolamide and Timolol?
Using these drugs together can cause their effects to stack up, which may lead to more side effects throughout your body.
Timolol's labeled portfolio outnumbers Dorzolamide
SPL source-record counts only. This page's band is moderate · classes on file: Dorzolamide (Carbonic Anhydrase Inhibitor (Ophthalmic)); Timolol (Beta-Blocker (Ophthalmic)).
0 major · 1 moderate · 1 minor · 2 total
Dorzolamide has no other moderate-band peer in this dataset besides Timolol.
0 major · 1 moderate · 5 minor · 6 total
Timolol has no other moderate-band peer in this dataset besides Dorzolamide.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.