Dorzolamide and Dorzolamide/Timolol Interaction
Drug interaction information between Dorzolamide and Dorzolamide/Timolol.
Dorzolamide and Dorzolamide/Timolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dorzolamide and Dorzolamide/Timolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking two drugs that both contain dorzolamide can cause the medicine to build up in your body and lead to chemical imbalances in your blood.
FDA Label Information
7.2 High-Dose Salicylate Therapy Although acid-base and electrolyte disturbances were not reported in the clinical trials with dorzolamide hydrochloride ophthalmic solution, these disturbances have been reported with oral carbonic anhydrase inhibitors and have, in some instances, resulted in drug interactions (e.g., toxicity associated with high-dose salicylate therapy).
Dorzolamide/Timolol Also Interacts With
View all Dorzolamide/Timolol interactions →Frequently Asked Questions
What SPL severity band is on file for Dorzolamide + Dorzolamide/Timolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dorzolamide/Timolol has 3 labeled pairs on file vs Dorzolamide's 2. In the minor band specifically: Dorzolamide has 1; Dorzolamide/Timolol has 3 (also Clonidine, Timolol).
What mechanism field is on file for Dorzolamide and Dorzolamide/Timolol?
Taking two drugs that both contain dorzolamide can cause the medicine to build up in your body and lead to chemical imbalances in your blood.
Dorzolamide/Timolol's labeled portfolio outnumbers Dorzolamide
SPL source-record counts only. This page's band is minor · classes on file: Dorzolamide (Carbonic Anhydrase Inhibitor (Ophthalmic)); Dorzolamide/Timolol (CAI / Beta-Blocker Combination (Ophthalmic)).
0 major · 1 moderate · 1 minor · 2 total
Dorzolamide has no other minor-band peer in this dataset besides Dorzolamide/Timolol.
0 major · 0 moderate · 3 minor · 3 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.