Prescription medicine
Dorzolamide First approved as Trusopt
Dorzolamide (Trusopt) is a prescription medicine with an FDA approval on record since 1994. FDA's NDC Directory lists it from 14 generic labelers, and pharmacies paid $0.835 per mL (Dorzolamide HCl 2% eye drops) in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the dorzolamide FDA label on DailyMed (effective June 29, 2026, Bausch & Lomb Incorporated); the NDA 20408 record on Drugs@FDA; every dorzolamide label on DailyMed.
Highlights of the record
FDA label of June 29, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageDorzolamide hydrochloride ophthalmic solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Forms and strengths
- 20 mg/ml
Solution/ drops; solution.
On the market
- Earliest approval on file
- December 9, 1994 Trusopt, Msd Sub Merck; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 14 first October 28, 2008; 10 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 14 of which 14 under generic applications, 0 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.835 per mL Dorzolamide HCl 2% eye drops
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 8,938 through July 30, 2026
What is dorzolamide used for?
From the label: indications and usageDorzolamide hydrochloride ophthalmic solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Dorzolamide hydrochloride ophthalmic solution is a carbonic anhydrase inhibitor indicated for the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Conditions named in the indications of dorzolamide's FDA labels, with every medicine labeled for each:
FDA pharmacologic class: Carbonic Anhydrase Inhibitor.
Source: FDA drug label (Dorzolamide HCl), Bausch & Lomb Incorporated, effective June 29, 2026 (SPL set 8417d162-65a1-4266-bca7-707af1193bf3), via openFDA; the full label on DailyMed
Is there a generic for dorzolamide (Trusopt)?
The FDA approved the first generic dorzolamide on October 28, 2008. 14 generic applications are approved; 10 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists dorzolamide from 14 labelers under a generic (ANDA) application. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1994 earliest approval on file
- 2008 first generic approved
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for dorzolamide (Trusopt)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.835 per mL (Dorzolamide HCl 2% eye drops), down 16% from $0.995 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Dorzolamide HCl 2% eye drops (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Dorzolamide HCl 2% eye drops | Generic | $0.835 per mL | n/a | -16% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What do FAERS reports show for dorzolamide?
The FDA Adverse Event Reporting System holds 8,938 reports that list dorzolamide among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 438 are coded as a death and 1,545 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is. Reports rose sharply in 2020 (2,429, against a median of 558 a year): FAERS counts follow reporting, which news, litigation and label changes can drive, not how often a reaction happens.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as dorzolamide?
16 other medicines are given the same way (ophthalmic) and in the same FDA class as dorzolamide or labeled mainly for the same use (glaucoma), the same class first. Glaucoma lists all 20 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (ophthalmic) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Brinzolamide | Glaucoma | 4 labelers | $9.00 per mL 1% eye drops | No current entry |
| Brimonidine and brinzolamide | Glaucoma | none listed | $26.04 per mL 1%-0.2% eye drop | No current entry |
| Timolol | Glaucoma | 21 labelers | $0.774 per mL 0.5% eye drops | No current entry |
| Brimonidine | Glaucoma | 12 labelers | $9.06 per mL 0.1% drop | No current entry |
| Bimatoprost | Glaucoma | 13 labelers | $6.97 per mL 0.03% eye drops | No current entry |
| Brimonidine and timolol | Glaucoma | 14 labelers | $2.15 per mL 0.2%-0.5% | No current entry |
| Latanoprost | Glaucoma | 14 labelers | $1.58 per mL 0.005% eye drops | No current entry |
| Travoprost | Glaucoma | 11 labelers | $9.07 per mL 0.004% eye drop | A presentation being discontinued |
Every medicine labeled for the same conditions as dorzolamide
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
How does dorzolamide compare with medicines for the same use?
3 side-by-side pages set dorzolamide beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.
What next?
- Alternatives to dorzolamide
- 16 medicines for the same use
- Other carbonic anhydrase inhibitors
- the pharmacologic class, with prices and generics
- Dorzolamide side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other