Disulfiram and Nabilone Interaction
Drug interaction information between Disulfiram and Nabilone.
Disulfiram and Nabilone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Disulfiram and Nabilone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two drugs together can cause a mood reaction that makes you feel unusually excited, restless, or energetic.
FDA Label Information
CONCOMITANT DRUG CLINICAL EFFECT(S) Amphetamines, cocaine, other sympathomimetic agents Additive hypertension, tachycardia, possibly cardiotoxicity Atropine, scopolamine, antihistamines, other anticholinergic agents Additive or super-additive tachycardia, drowsiness Amitriptyline, amoxapine, desipramine, other tricyclic antidepressants Additive tachycardia, hypertension, drowsiness Barbiturates, benzodiazepines, ethanol, lithium, opioids, buspirone, antihistamines, muscle relaxants, other CNS depressants Additive drowsiness and CNS depression Disulfiram A reversible hypomanic reaction was...
Disulfiram Also Interacts With
- Phenytoin moderate
- Acamprosate minor
- Amitriptyline minor
- Metronidazole minor
- Naltrexone minor
Nabilone Also Interacts With
- Fluoxetine minor
- Buspirone minor
- Amitriptyline minor
- Diazepam minor
- Lithium minor
Frequently Asked Questions
What SPL severity band is on file for Disulfiram + Nabilone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nabilone has 11 labeled pairs on file vs Disulfiram's 8. In the minor band specifically: Disulfiram has 7 (also Acamprosate, Amitriptyline, Metronidazole, Naltrexone); Nabilone has 11 (also Fluoxetine, Buspirone, Amitriptyline, Diazepam).
What mechanism field is on file for Disulfiram and Nabilone?
Using these two drugs together can cause a mood reaction that makes you feel unusually excited, restless, or energetic.
Nabilone's labeled portfolio outnumbers Disulfiram
SPL source-record counts only. This page's band is minor · classes on file: Disulfiram (Aldehyde Dehydrogenase Inhibitor); Nabilone (Cannabinoid Antiemetic).
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Disulfiram
- Acamprosate
- Amitriptyline
- Metronidazole
- Naltrexone
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Nabilone
- Fluoxetine
- Buspirone
- Amitriptyline
- Diazepam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.