Disulfiram and Acamprosate Interaction
Drug interaction information between Disulfiram and Acamprosate.
Disulfiram and Acamprosate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Disulfiram and Acamprosate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Disulfiram does not change the way your body breaks down or uses acamprosate.
FDA Label Information
The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram, and clinically important interactions between naltrexone and acamprosate were not observed [ see Clinical Pharmacology (12.3) ].
Disulfiram Also Interacts With
- Phenytoin moderate
- Amitriptyline minor
- Metronidazole minor
- Nabilone minor
- Naltrexone minor
Frequently Asked Questions
What SPL severity band is on file for Disulfiram + Acamprosate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Disulfiram has 8 labeled pairs on file vs Acamprosate's 3. In the minor band specifically: Disulfiram has 7 (also Amitriptyline, Metronidazole, Nabilone, Naltrexone); Acamprosate has 3 (also Diazepam, Naltrexone).
What mechanism field is on file for Disulfiram and Acamprosate?
Disulfiram does not change the way your body breaks down or uses acamprosate.
Disulfiram's labeled portfolio outnumbers Acamprosate
SPL source-record counts only. This page's band is minor · classes on file: Disulfiram (Aldehyde Dehydrogenase Inhibitor); Acamprosate (GABA Analog (Alcohol Dependence)).
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Disulfiram
- Amitriptyline
- Metronidazole
- Nabilone
- Naltrexone
0 major · 0 moderate · 3 minor · 3 total
- Other minor peers for Acamprosate
- Diazepam
- Naltrexone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.