Disulfiram and Amitriptyline Interaction
Drug interaction information between Disulfiram and Amitriptyline.
Disulfiram and Amitriptyline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Disulfiram and Amitriptyline. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Disulfiram can interfere with how your liver breaks down amitriptyline. This can lead to higher levels of the medication in your system.
What To Do
Use this combination with caution and follow your doctor's instructions for monitoring your symptoms.
FDA Label Information
Guanethidine or similarly acting compounds; thyroid medication; alcohol, barbiturates and other CNS depressants; and disulfiram – see WARNINGS section.
Disulfiram Also Interacts With
- Phenytoin moderate
- Acamprosate minor
- Metronidazole minor
- Nabilone minor
- Naltrexone minor
Amitriptyline Also Interacts With
- Risperidone major
- Sertraline minor
- Fluoxetine minor
- Paroxetine minor
- Flecainide minor
Frequently Asked Questions
Can I take Disulfiram and Amitriptyline together?
This is a minor interaction. Use this combination with caution and follow your doctor's instructions for monitoring your symptoms.
How serious is the interaction between Disulfiram and Amitriptyline?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Disulfiram and Amitriptyline interact?
Disulfiram can interfere with how your liver breaks down amitriptyline. This can lead to higher levels of the medication in your system.
Understanding the Disulfiram and Amitriptyline Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Disulfiram belongs to the Aldehyde Dehydrogenase Inhibitor class and Amitriptyline belongs to the Tricyclic Antidepressant (TCA) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Disulfiram can interfere with how your liver breaks down amitriptyline. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Disulfiram has 8 total documented interactions on file in this dataset, and Amitriptyline has 21. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Use this combination with caution and follow your doctor's instructions for monitoring your symptoms. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Disulfiram or Amitriptyline based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.