Disulfiram and Amitriptyline Interaction
Drug interaction information between Disulfiram and Amitriptyline.
Disulfiram and Amitriptyline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Disulfiram and Amitriptyline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Disulfiram can interfere with how your liver breaks down amitriptyline. This can lead to higher levels of the medication in your system.
FDA Label Information
Guanethidine or similarly acting compounds; thyroid medication; alcohol, barbiturates and other CNS depressants; and disulfiram – see WARNINGS section.
Disulfiram Also Interacts With
- Phenytoin moderate
- Acamprosate minor
- Metronidazole minor
- Nabilone minor
- Naltrexone minor
Amitriptyline Also Interacts With
- Risperidone major
- Sertraline minor
- Fluoxetine minor
- Paroxetine minor
- Flecainide minor
Frequently Asked Questions
What SPL severity band is on file for Disulfiram + Amitriptyline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amitriptyline has 21 labeled pairs on file vs Disulfiram's 8. In the minor band specifically: Disulfiram has 7 (also Acamprosate, Metronidazole, Nabilone, Naltrexone); Amitriptyline has 20 (also Sertraline, Fluoxetine, Paroxetine, Flecainide).
What mechanism field is on file for Disulfiram and Amitriptyline?
Disulfiram can interfere with how your liver breaks down amitriptyline. This can lead to higher levels of the medication in your system.
Amitriptyline carries more major-labeled pairs than Disulfiram
SPL source-record counts only. This page's band is minor · classes on file: Disulfiram (Aldehyde Dehydrogenase Inhibitor); Amitriptyline (Tricyclic Antidepressant (TCA)).
Amitriptyline has 1 major-labeled pair vs Disulfiram's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Disulfiram
- Acamprosate
- Metronidazole
- Nabilone
- Naltrexone
1 major · 0 moderate · 20 minor · 21 total
- Other minor peers for Amitriptyline
- Sertraline
- Fluoxetine
- Paroxetine
- Flecainide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.