Disulfiram and Naltrexone Interaction
Drug interaction information between Disulfiram and Naltrexone.
Disulfiram and Naltrexone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Disulfiram and Naltrexone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these medications can be hard on the liver. Using them at the same time may increase your risk of developing liver problems.
What To Do
This combination is usually avoided unless your doctor decides the benefits are worth the risk. Your doctor should check your liver function regularly.
FDA Label Information
The safety and efficacy of concomitant use of naltrexone hydrochloride and disulfiram is unknown, and the concomitant use of two potentially hepatotoxic medications is not ordinarily recommended unless the probable benefits outweigh the known risks.
Disulfiram Also Interacts With
- Phenytoin moderate
- Acamprosate minor
- Amitriptyline minor
- Metronidazole minor
- Nabilone minor
Naltrexone Also Interacts With
- Thioridazine minor
- Acamprosate minor
- Glecaprevir/Pibrentasvir minor
- Nabilone minor
Frequently Asked Questions
Can I take Disulfiram and Naltrexone together?
This is a minor interaction. This combination is usually avoided unless your doctor decides the benefits are worth the risk. Your doctor should check your liver function regularly.
How serious is the interaction between Disulfiram and Naltrexone?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Disulfiram and Naltrexone interact?
Both of these medications can be hard on the liver. Using them at the same time may increase your risk of developing liver problems.
Understanding the Disulfiram and Naltrexone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Disulfiram belongs to the Aldehyde Dehydrogenase Inhibitor class and Naltrexone belongs to the Opioid Antagonist class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these medications can be hard on the liver. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Disulfiram has 8 total documented interactions on file in this dataset, and Naltrexone has 5. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: This combination is usually avoided unless your doctor decides the benefits are worth the risk. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Disulfiram or Naltrexone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.