Diazoxide and Glimepiride Interaction
Drug interaction information between Diazoxide and Glimepiride.
Diazoxide and Glimepiride have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diazoxide and Glimepiride. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Diazoxide can cause blood sugar to rise, which prevents glimepiride from working as well as it should.
What To Do
Your doctor may need to check your blood sugar more frequently and might change your dose.
FDA Label Information
The following are examples of medications that may reduce the glucose-lowering effect of sulfonylureas including glimepiride, leading to worsening glycemic control: danazol, glucagon, somatropin, protease inhibitors, atypical antipsychotic medications (e.g., olanzapine and clozapine), barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics (e.g., epinephrine, albuterol, terbutaline), and isoniazid.
Glimepiride Also Interacts With
- Albuterol minor
- Fluoxetine minor
- Clonidine minor
- Olanzapine minor
- Fluconazole minor
Frequently Asked Questions
Can I take Diazoxide and Glimepiride together?
This is a minor interaction. Your doctor may need to check your blood sugar more frequently and might change your dose.
How serious is the interaction between Diazoxide and Glimepiride?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Diazoxide and Glimepiride interact?
Diazoxide can cause blood sugar to rise, which prevents glimepiride from working as well as it should.
Understanding the Diazoxide and Glimepiride Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Diazoxide belongs to the Potassium Channel Opener (Hyperinsulinism) class and Glimepiride belongs to the Sulfonylurea class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Diazoxide can cause blood sugar to rise, which prevents glimepiride from working as well as it should. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Diazoxide has 3 total documented interactions on file in this dataset, and Glimepiride has 16. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to check your blood sugar more frequently and might change your dose. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Diazoxide or Glimepiride based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.