Diazoxide and Raloxifene Interaction

Drug interaction information between Diazoxide and Raloxifene.

Diazoxide and Raloxifene have a documented moderate interaction in FDA labeling.

FDA drug labeling documents a moderate-severity interaction between Diazoxide and Raloxifene. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.

Drug A

Diazoxide

Potassium Channel Opener (Hyperinsulinism)

Drug B

Raloxifene

Selective Estrogen Receptor Modulator (SERM)

How They Interact

These drugs compete for the same binding spots on proteins in your bloodstream. This competition can change how much of each drug is active in your body at one time.

FDA Label Information

Highly protein-bound drugs include diazepam, diazoxide, and lidocaine. 7.3 Other Highly Protein-Bound Drugs Raloxifene hydrochloride should be used with caution with certain other highly protein-bound drugs such as diazepam, diazoxide, and lidocaine.

Frequently Asked Questions

What SPL severity band is on file for Diazoxide + Raloxifene?

Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.

Which drug in this pair has the larger labeled-interaction portfolio?

Raloxifene has 7 labeled pairs on file vs Diazoxide's 3. In the moderate band specifically: Diazoxide has 1; Raloxifene has 3 (also Diazepam, Cholestyramine).

What mechanism field is on file for Diazoxide and Raloxifene?

These drugs compete for the same binding spots on proteins in your bloodstream. This competition can change how much of each drug is active in your body at one time.

Raloxifene's labeled portfolio outnumbers Diazoxide

SPL source-record counts only. This page's band is moderate · classes on file: Diazoxide (Potassium Channel Opener (Hyperinsulinism)); Raloxifene (Selective Estrogen Receptor Modulator (SERM)).

Diazoxide

0 major · 1 moderate · 2 minor · 3 total

Diazoxide has no other moderate-band peer in this dataset besides Raloxifene.

Raloxifene

0 major · 3 moderate · 4 minor · 7 total

Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.