Diazoxide and Phenytoin Interaction
Drug interaction information between Diazoxide and Phenytoin.
Diazoxide and Phenytoin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diazoxide and Phenytoin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diazoxide can lower the amount of phenytoin in your blood, which might make your seizure medicine work less effectively.
Diazoxide Also Interacts With
- Raloxifene moderate
- Glimepiride minor
Phenytoin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Posaconazole major
- Ranolazine major
- Voriconazole major
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Diazoxide + Phenytoin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenytoin has 147 labeled pairs on file vs Diazoxide's 3. In the minor band specifically: Diazoxide has 2 (also Glimepiride); Phenytoin has 120 (also Atorvastatin, Omeprazole, Simvastatin, Methylphenidate).
What mechanism field is on file for Diazoxide and Phenytoin?
Diazoxide can lower the amount of phenytoin in your blood, which might make your seizure medicine work less effectively.
Phenytoin carries more major-labeled pairs than Diazoxide
SPL source-record counts only. This page's band is minor · classes on file: Diazoxide (Potassium Channel Opener (Hyperinsulinism)); Phenytoin (Anticonvulsant (Hydantoin)).
Phenytoin has 4 major-labeled pairs vs Diazoxide's 0. This page itself is in the minor band, not the major band.
4 major · 23 moderate · 120 minor · 147 total
- Other minor peers for Phenytoin
- Atorvastatin
- Omeprazole
- Simvastatin
- Methylphenidate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.