desvenlafaxine vs warfarin
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Side-by-side comparison of desvenlafaxine and warfarin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Table 3: Drugs that Can Increase the Risk of Bleeding Drug Class Specific Drugs Anticoagulants argatroban, dabigatran, bivalirudin, desirudin, heparin, lepirudin Antiplatelet Agents aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticlopidine Non-steroidal Anti-Inflammatory Agents celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac Serotonin Reuptake Inhibitors citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline,...
Pristiq
Coumadin, Jantoven
Pristiq is a medicine used to treat depression in adults. It belongs to a class of drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs).
Warfarin is a medicine that helps prevent blood clots. It is used to treat and prevent dangerous clots from forming in your body.
Pristiq is used to treat major depressive disorder (MDD) in adults. MDD can cause you to feel sad, lose interest in activities, and have trouble with daily life. This medicine can help improve your mood and energy levels.
Warfarin is used to prevent and treat blood clots in your veins and lungs. It can also prevent clots if you have atrial fibrillation (irregular heartbeat) or a replacement heart valve. After a heart attack, it can lower the risk of death, another heart attack, or a stroke.
Pristiq works by affecting certain chemicals in the brain. It increases the levels of serotonin and norepinephrine. These chemicals help regulate mood and can improve symptoms of depression.
Warfarin works by blocking your body's use of vitamin K. Vitamin K is needed to make blood clotting factors. By blocking vitamin K, warfarin makes your blood less likely to clot.
- • Feeling sick to your stomach
- • Feeling dizzy
- • Trouble sleeping
- • Increased sweating
- • Constipation
- • Bleeding from any tissue or organ
- Toxicity To Various Agents 233
- Nausea 206
- Completed Suicide 186
- Anxiety 180
- Overdose 174
- International Normalised Ratio Increased 10,276
- Dyspnoea 8,408
- Drug Interaction 6,288
- Fatigue 6,143
- Nausea 5,921
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults. If you are started on Pristiq, your doctor will monitor you closely for worsening depression or suicidal thoughts. Families and caregivers should also watch for these changes.
Warfarin can cause major or fatal bleeding. You must have your blood tested regularly (INR) while taking warfarin. Many things, like other medicines and diet changes, can affect your INR. Tell your doctor about any bleeding and follow their instructions to prevent bleeding.
Tell your doctor if you are pregnant or plan to become pregnant. Taking Pristiq late in pregnancy may cause problems in the newborn. There is a pregnancy registry to monitor outcomes in women exposed to antidepressants during pregnancy. You can register by calling 1-844-405-6185.
Warfarin can harm your unborn baby, especially during the first three months of pregnancy. Do not take warfarin if you are pregnant, unless you have a mechanical heart valve and your doctor says the benefits outweigh the risks. Talk to your doctor if you are breastfeeding, and watch your baby for bruising or bleeding.
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How to Read This desvenlafaxine vs warfarin Comparison
desvenlafaxine is classified in the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) drug class, while warfarin sits within the Vitamin K Antagonist (Anticoagulant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, desvenlafaxine has 979 submissions while warfarin has 37,036. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to desvenlafaxine is an antidepressant that can increase the risk of bleeding when combined with warfarin. it affects how your blood cells work together to stop bleeding.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for desvenlafaxine or warfarin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.