What the FDA labels say about taking them together
Vilazodone and warfarin
Vilazodone's FDA label of May 22, 2024 names warfarin in its drug interactions section, and warfarin's label names vilazodone too. The vilazodone label: “For patients taking warfarin, carefully monitor the international normalized ratio (INR) when initiating, titrating, or discontinuing VIIBRYD.”
Check it at the source: the vilazodone FDA label on DailyMed (effective May 22, 2024, Teva Pharmaceuticals, Inc.); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the vilazodone label say about warfarin?
Vilazodone label, drug interactionsFor patients taking warfarin, carefully monitor the international normalized ratio (INR) when initiating, titrating, or discontinuing vilazodone hydrochloride [see Warnings and Precautions ( 5.3 )].
Vilazodone label, warnings and precautionsConcomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk. ( 5.3 ) Activation of Mania/Hypomania:
Source: FDA drug label (Viibryd, NDA022567), Allergan, Inc., effective October 1, 2023 (SPL set 4c55ccfb-c4cf-11df-851a-0800200c9a66), via openFDA
Source: FDA drug label (Vilazodone Hydrochloride), Teva Pharmaceuticals, Inc., effective May 22, 2024 (SPL set 3a4745a0-de23-4b40-923e-0d7dfe6b8634), via openFDA; the full label on DailyMed
What does the warfarin label say about vilazodone?
Warfarin label, drug interactionsDrug Class: Serotonin Reuptake Inhibitors; Specific Drugs: citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline, venlafaxine, vilazodone
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Vilazodone | Warfarin | |
|---|---|---|
| Labeled for | Depression | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.732 per tablet 10 mg tablet | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once