Desloratadine and Azithromycin Interaction
Drug interaction information between Desloratadine and Azithromycin.
Desloratadine and Azithromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Desloratadine and Azithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Azithromycin blocks the enzymes that normally clear desloratadine from your system, causing the allergy medicine to stay in your body longer. Even though levels go up, it does not typically cause harmful effects.
FDA Label Information
7 DRUG INTERACTIONS 7.1 Inhibitors of Cytochrome P450 3A4 In controlled clinical studies co-administration of desloratadine with ketoconazole, erythromycin, or azithromycin resulted in increased plasma concentrations of desloratadine and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of desloratadine.
Desloratadine Also Interacts With
- Fluoxetine minor
- Ketoconazole minor
- Erythromycin minor
- Cimetidine minor
Azithromycin Also Interacts With
- Theophylline major
- Warfarin minor
- Digoxin minor
- Colchicine minor
- Phenytoin minor
Frequently Asked Questions
What SPL severity band is on file for Desloratadine + Azithromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Azithromycin has 9 labeled pairs on file vs Desloratadine's 5. In the minor band specifically: Desloratadine has 5 (also Fluoxetine, Ketoconazole, Erythromycin, Cimetidine); Azithromycin has 8 (also Warfarin, Digoxin, Colchicine, Phenytoin).
What mechanism field is on file for Desloratadine and Azithromycin?
Azithromycin blocks the enzymes that normally clear desloratadine from your system, causing the allergy medicine to stay in your body longer. Even though levels go up, it does not typically cause harmful effects.
Azithromycin carries more major-labeled pairs than Desloratadine
SPL source-record counts only. This page's band is minor · classes on file: Desloratadine (Second-Generation Antihistamine); Azithromycin (Macrolide Antibiotic).
Azithromycin has 1 major-labeled pair vs Desloratadine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 5 minor · 5 total
- Other minor peers for Desloratadine
- Fluoxetine
- Ketoconazole
- Erythromycin
- Cimetidine
1 major · 0 moderate · 8 minor · 9 total
- Other minor peers for Azithromycin
- Warfarin
- Digoxin
- Colchicine
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.