azithromycin vs desloratadine
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Side-by-side comparison of azithromycin and desloratadine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7 DRUG INTERACTIONS 7.1 Inhibitors of Cytochrome P450 3A4 In controlled clinical studies co-administration of desloratadine with ketoconazole, erythromycin, or azithromycin resulted in increased plasma concentrations of desloratadine and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of desloratadine.
Zithromax, Z-Pack
Clarinex
Azithromycin is an antibiotic that fights bacteria. It is used to treat many different types of infections.
Desloratadine is an antihistamine medicine. It helps relieve allergy symptoms.
Azithromycin treats mild to moderate infections caused by certain bacteria. In adults, it can treat bronchitis, sinus infections, skin infections, urethritis, cervicitis, and genital ulcers. In children over 6 months old, it can treat ear infections and pneumonia. It can also treat pharyngitis/tonsillitis in children 2 years and older.
This medicine treats allergy symptoms. It can help with seasonal allergies like hay fever. It also treats year-round allergies and chronic hives by reducing itching and the number and size of hives.
Azithromycin belongs to a class of drugs called macrolide antibiotics. It works by stopping the growth of bacteria. This helps your body fight off the infection.
Desloratadine blocks histamine in your body. Histamine is a substance that causes allergy symptoms. By blocking histamine, this medicine reduces those symptoms.
- • Diarrhea (5-14%)
- • Nausea (3-18%)
- • Abdominal pain (3-7%)
- • Vomiting (2-7%)
- • Sore throat
- • Dry mouth
- • Muscle pain
- • Tiredness
- • Sleepiness
- Dyspnoea 3,059
- Nausea 2,232
- Pain 2,205
- Pneumonia 2,085
- Cough 2,031
- Fatigue 601
- Nausea 582
- Dyspnoea 532
- Headache 465
- Diarrhoea 448
This drug can cause serious allergic reactions, liver problems, and heart rhythm changes. Tell your doctor right away if you have signs of an allergic reaction, like rash or swelling. Also, tell your doctor if you have liver problems, heart problems, or muscle weakness.
Stop taking this medicine and get medical help right away if you have an allergic reaction. Signs of a reaction include rash, itching, hives, swelling, trouble breathing, or anaphylaxis.
Studies haven't shown major risks to the baby during pregnancy. Talk to your doctor if you are pregnant or breastfeeding before taking this medicine.
Not enough studies have been done to know if desloratadine is safe during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if desloratadine passes into breast milk.
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How to Read This azithromycin vs desloratadine Comparison
azithromycin is classified in the Macrolide Antibiotic drug class, while desloratadine sits within the Second-Generation Antihistamine class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, azithromycin has 11,612 submissions while desloratadine has 2,628. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to azithromycin blocks the enzymes that normally clear desloratadine from your system, causing the allergy medicine to stay in your body longer. even though levels go up, it does not typically cause harmful effects.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for azithromycin or desloratadine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.