Azithromycin and Theophylline Interaction
Drug interaction information between Azithromycin and Theophylline.
Azithromycin and Theophylline have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Azithromycin and Theophylline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Azithromycin does not significantly change the levels of theophylline in your body.
FDA Label Information
albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit theophylline absorption) isoniazid sucralfate isradipine terbutaline,...
Azithromycin Also Interacts With
- Warfarin minor
- Digoxin minor
- Colchicine minor
- Phenytoin minor
- Desloratadine minor
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Frequently Asked Questions
What SPL severity band is on file for Azithromycin + Theophylline?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Azithromycin's 9. In the major band specifically: Azithromycin has 1; Theophylline has 27 (also Metoprolol, Albuterol, Omeprazole, Amoxicillin).
What mechanism field is on file for Azithromycin and Theophylline?
Azithromycin does not significantly change the levels of theophylline in your body.
Theophylline carries more major-labeled pairs than Azithromycin
SPL source-record counts only. This page's band is major · classes on file: Azithromycin (Macrolide Antibiotic); Theophylline (Methylxanthine Bronchodilator).
Theophylline has 27 major-labeled pairs vs Azithromycin's 1.
1 major · 0 moderate · 8 minor · 9 total
Azithromycin has no other major-band peer in this dataset besides Theophylline.
27 major · 5 moderate · 54 minor · 86 total
- Other major peers for Theophylline
- Metoprolol
- Albuterol
- Omeprazole
- Amoxicillin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.