What the FDA labels say about taking them together
Azithromycin and phenytoin
Azithromycin's FDA label of December 4, 2025 names phenytoin in its drug interactions section; the phenytoin labels PlainMeds reads (2) do not name azithromycin. The azithromycin label: “Until further data are developed regarding drug interactions when digoxin, colchicine or phenytoin are used with azithromycin careful monitoring of patients is advised.”
Check it at the source: the azithromycin FDA label on DailyMed (effective December 4, 2025, Bionpharma Inc.); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the azithromycin label say about phenytoin?
Azithromycin label, drug interactionsUntil further data are developed regarding drug interactions when digoxin, colchicine or phenytoin are used with azithromycin careful monitoring of patients is advised.
Source: FDA drug label (Azithromycin), Bionpharma Inc., effective December 4, 2025 (SPL set 859bb02c-a4bc-46fa-9fc9-def1219b5dfb), via openFDA; the full label on DailyMed
What does the phenytoin label say about azithromycin?
Phenytoin's label (effective October 15, 2024) and its 1 other brand-application label do not name azithromycin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Azithromycin | Phenytoin | |
|---|---|---|
| Labeled for | Bacterial infections | Seizures and epilepsy |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.266 per tablet 250 mg tablet | $0.145 per capsule 100 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once