Desloratadine and Cimetidine Interaction
Drug interaction information between Desloratadine and Cimetidine.
Desloratadine and Cimetidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Desloratadine and Cimetidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine slows down the liver's ability to process desloratadine, which leads to higher levels of the medicine in your blood.
FDA Label Information
[ See Clinical Pharmacology (12.3) .] 7.3 Cimetidine In controlled clinical studies co-administration of desloratadine with cimetidine, a histamine H 2 -receptor antagonist, resulted in increased plasma concentrations of desloratadine and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of desloratadine.
Desloratadine Also Interacts With
- Fluoxetine minor
- Azithromycin minor
- Ketoconazole minor
- Erythromycin minor
Cimetidine Also Interacts With
- Levofloxacin major
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Desloratadine + Cimetidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Desloratadine's 5. In the minor band specifically: Desloratadine has 5 (also Fluoxetine, Azithromycin, Ketoconazole, Erythromycin); Cimetidine has 63 (also Albendazole, Alogliptin, Alosetron, Alprazolam).
What mechanism field is on file for Desloratadine and Cimetidine?
Cimetidine slows down the liver's ability to process desloratadine, which leads to higher levels of the medicine in your blood.
Cimetidine carries more major-labeled pairs than Desloratadine
SPL source-record counts only. This page's band is minor · classes on file: Desloratadine (Second-Generation Antihistamine); Cimetidine (H2 Receptor Antagonist).
Cimetidine has 4 major-labeled pairs vs Desloratadine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 5 minor · 5 total
- Other minor peers for Desloratadine
- Fluoxetine
- Azithromycin
- Ketoconazole
- Erythromycin
4 major · 10 moderate · 63 minor · 77 total
- Other minor peers for Cimetidine
- Albendazole
- Alogliptin
- Alosetron
- Alprazolam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.