What the FDA labels say about taking them together
Cimetidine and desloratadine
Desloratadine's FDA label of May 17, 2025 names cimetidine in its drug interactions section; the cimetidine label PlainMeds reads does not name desloratadine. The desloratadine label: “In controlled clinical studies co-administration of desloratadine with cimetidine, a histamine H2-receptor antagonist, resulted in increased plasma concentrations of desloratadine and 3 hydroxydesloratadine, but there …”
Check it at the source: the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.); the desloratadine FDA label on DailyMed (effective May 17, 2025, Organon LLC).
What does the cimetidine label say about desloratadine?
Cimetidine's label (effective July 15, 2026) does not name desloratadine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
What does the desloratadine label say about cimetidine?
Desloratadine label, drug interactionsIn controlled clinical studies co-administration of desloratadine with cimetidine, a histamine H2-receptor antagonist, resulted in increased plasma concentrations of desloratadine and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of desloratadine. [See Clinical Pharmacology (12.3) .]
Source: FDA drug label (Clarinex), Organon LLC, effective May 17, 2025 (SPL set c671342e-69a2-4ca5-abc2-8166ed4240d4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cimetidine | Desloratadine | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Allergies |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.236 per tablet 300 mg tablet | $0.258 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once