Azithromycin and Colchicine Interaction
Drug interaction information between Azithromycin and Colchicine.
Azithromycin and Colchicine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Azithromycin and Colchicine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
It is not yet known exactly how these drugs interact, but azithromycin may potentially change the levels of colchicine in your body.
FDA Label Information
7.3 Potential Drug-Drug Interaction with Macrolides Interactions with digoxin, colchicine or phenytoin have not been reported in clinical trials with azithromycin. Until further data are developed regarding drug interactions when digoxin, colchicine or phenytoin are used with azithromycin careful monitoring of patients is advised.
Azithromycin Also Interacts With
- Theophylline major
- Warfarin minor
- Digoxin minor
- Phenytoin minor
- Desloratadine minor
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Azithromycin + Colchicine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colchicine has 28 labeled pairs on file vs Azithromycin's 9. In the minor band specifically: Azithromycin has 8 (also Warfarin, Digoxin, Phenytoin, Desloratadine); Colchicine has 15 (also Estradiol, Diltiazem, Norethindrone, Ketoconazole).
What mechanism field is on file for Azithromycin and Colchicine?
It is not yet known exactly how these drugs interact, but azithromycin may potentially change the levels of colchicine in your body.
Colchicine carries more major-labeled pairs than Azithromycin
SPL source-record counts only. This page's band is minor · classes on file: Azithromycin (Macrolide Antibiotic); Colchicine (Anti-Gout Agent).
Colchicine has 4 major-labeled pairs vs Azithromycin's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 8 minor · 9 total
- Other minor peers for Azithromycin
- Warfarin
- Digoxin
- Phenytoin
- Desloratadine
4 major · 9 moderate · 15 minor · 28 total
- Other minor peers for Colchicine
- Estradiol
- Diltiazem
- Norethindrone
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.